Factors may also relate to the implementation and effectiveness of antenatal screening.
Following the initial search, LS collated records and uploaded them into Rayyan [ 14 ] to facilitate screening. After removal of duplicates, two independent reviewers (LS and FM) screened titles and abstracts for relevance and assessed full text of potentially relevant article using the inclusion criteria. Those meeting inclusion criteria at full-text screen were included in our results. Any discrepancies were resolved through discussion or consultation with a third reviewer (NS) when needed.
We used a standard form to extract key information including study characteristics (author, year, country, urban/rural setting, diseases considered), study design, sample, aim, identified significant barriers and facilitators to screening (e.g., odds ratios at the 95% confidence interval, p-value < 0.05). We thematically analysed qualitative articles through an iterative process of reading and coding them using Andersen’s framework [ 15 ]. This theoretical framework widely used in literature reviews on healthcare utilisation [ 16 ] provides understanding of how individuals and environmental factors influence health behaviours. The framework categorises predictors of health service use as i) Predisposing characteristics including demographic factors, social structure, and health beliefs that influence health services use. ii) Enabling factors allowing the individual to seek health services if needed. iii) Need factors including perceived needs of healthcare services use.
LS and FM assessed the quality of included studies using tools appropriate to the study design. The quality of the studies included was evaluated based on Von Elm et al’s [ 17 ] checklist for observational studies and O’Brien et al’s [ 18 ] checklist for qualitative studies. S2 and S3 Tables present the quality appraisal checklists for the considered studies. We scored each paper based on how many checklist items were met. Overall, papers that met over 75% of the checklist items were considered to be of high quality, those meeting 50% to 75% of the checklist were regarded as moderate quality, and those meeting less than 50% poor quality. Because the aim was to describe and synthesise a body of the literature and not determine an effect size, studies were not excluded based on quality.
Descriptive characteristics of research studies were presented in tables. A narrative synthesis (Popay et al. 2006) was conducted to summarize the findings of the included studies. We did not combine quantitative estimates because of the heterogeneity of approaches and findings. Themes and patterns related to factors influencing screening uptake were identified and analysed and the final set of barriers and facilitators categorised according to Andersen [ 15 ]’s conceptual model.
After the selection process, 23 articles met the eligibility criteria and were included in the review. The PRISMA diagram provides an overview of the selection process ( Fig 1 ).
Details about the articles included are presented in Table 2 . Most included studies were on HIV screening, one was on syphilis screening [ 19 ], one on HIV and syphilis [ 20 ] and one on HIV, syphilis and hepatitis B [ 21 ]. Eight out of the 23 studies used data collected after 2015 [ 20 , 22 – 28 ]. Six of the studies were conducted in Vietnam, five in India, three in Indonesia, two in Cambodia, and one each in Hong Kong, Mongolia, China, Afghanistan and Thailand. Nineteen of the studies (83%) used quantitative methods, three (15%) used qualitative methods, and one (2%) used mixed methods.
Citation | Date | Country | Urban/ rural | Disease | Sample | Study type | Aim |
---|---|---|---|---|---|---|---|
Dinh [ ] | 2005 | Vietnam | Urban | HIV | 500 pregnant women 18 aged years and older who were first-time antenatal care (ANC) visitors and had never been tested or were unaware of their results | Quantitative | Identify the factors associated with declining HIV antenatal screening and the failure to return for results |
Nguyen [ ] | 2010 | Vietnam | Urban | HIV | 300 women who had recently delivered | Quantitative | Describe the uptake of antenatal HIV screening |
Hạnh [ ] | 2011 | Vietnam | Urban/ rural | HIV | 1108 nursing mothers | Quantitative | Assess early uptake of HIV screening and the provision of HIV counselling among pregnant women |
Pharris [ ] | 2011 | Vietnam | Urban | HIV | 1108 pregnant women who attend antenatal care at primary and higher-level health facilities | Quantitative | Assess early uptake of HIV testing and the provision of HIV counselling among pregnant women |
Khuu [ ] | 2018 | Vietnam | Urban | HIV | 320 women who were tested during ANC | Quantitative | Identify reasons for late HIV screening among pregnant women |
Chu [ ] | 2019 | Vietnam | Urban/ rural | HIV | 1484 women aged 15 to 49 years having a live birth within the last 2 years | Quantitative | Assess the socioeconomic inequalities in HIV screening during ANC |
Bharucha [ ] | 2005 | India | Urban | HIV | 6,702 pregnant women presenting in labour | Quantitative | Explore factors affecting the eligibility and acceptability of voluntary counselling and rapid HIV testing |
Rogers [ ] | 2006 | India | Rural | HIV | 202 pregnant women attending a rural ANC clinic | Quantitative | Investigate HIV-related knowledge, attitudes toward infant feeding practices, and perceived benefits and risks of HIV screening |
Sinha [ ] | 2008 | India | Rural | HIV | 400 women that have gave birth in the previous 12 months | Quantitative | Investigate HIV screening among rural women during pregnancy |
Sarin [ ] | 2013 | India | Rural | HIV | 357 women who had given birth in the last two years | Quantitative | Examine the prevalence and the barriers to HIV screening among pregnant women vulnerable to HIV due to their spouses’ risky behaviours |
Sharma [ ] | 2022 | India | Urban/ rural | HIV | 122,351 women aged 15–49 | Quantitative | Determine the factor associated with HIV screening during ANC |
Lubis [ ] | 2019 | Indonesia | Urban/ rural | HIV | 20 private midwives | Qualitative | Examine midwives’ perceptions of barriers and enabling factors about referring pregnant women for HIV screening |
Wulandari [ ] | 2019 | Indonesia | Urban/ rural | HIV | 619 women to voluntary HIV counselling and screening clinics | Quantitative | Examine the rates of HIV screening uptake among pregnant women attending private midwife clinics |
Baker [ ] | 2020 | Indonesia | Rural | HIV, syphilis | 3382 pregnant women and 40 health workers involved in screening | Mixed-methods | Explore current practice, barriers and facilitators in the delivery of antenatal testing for anaemia, HIV and syphilis |
Pakki [ ] | 2020 | Indonesia | Rural | HIV | 42 health workers managers | Quantitative | Investigate the influence of training given to health workers on HIV testing uptake by pregnant women |
Setiyawati [ ] | 2021 | Indonesia | Urban | HIV | 350 housewives in districts that already implemented prevention mother-to-child transmission program | Quantitative | Assess the factors that influence the housewife attitude toward HIV testing |
Kakimoto [ ] | 2007 | Cambodia | Urban | HIV | 315 mothers who came to a childhood immunization with a child aged 6–24 months | Quantitative | Assess predictive determinants for HIV testing |
Sasaki [ ] | 2010 | Cambodia | Urban | HIV | 600 eligible mothers who were admitted to the hospital after delivery | Quantitative | Assess the prevalence of and barriers to HIV screening |
Lee [ ] | 2005 | Hong Kong | Urban | HIV | 3,500 pregnant women attending their first ANC visit | Quantitative | Investigate acceptance of universal HIV antibody screening programme |
Munkhuu [ ] | 2006 | Mongolia | Urban | Syphilis | 150 ANC providers and 27 senior doctors | Qualitative | Assess ANC providers’ practices and opinions toward antenatal syphilis screening |
Todd [ ] | 2008 | Afghanistan | Urban | HIV, syphilis, hepatitis B | 114 doctors and midwives | Quantitative | Determine attitudes toward and utilization of testing for HIV, syphilis, and hepatitis B among obstetric care providers |
Crozier [ ] | 2013 | Thailand | Urban | HIV | 38 migrant pregnant women who had been through the HIV screening process 2013and 26 health personnel | Qualitative | Explore factors that relate to HIV screening decisions for migrant women |
Li [ ] | 2014 | China | Urban | HIV | 500 pregnant women recruited during their antenatal visit | Quantitative | Assess the prevalence of the willingness for HIV testing among pregnant women and cognitive factors associated with it |
In the four studies that used qualitative methods, pregnant women were interviewed as well as other individuals such as health providers, district managers, husbands, and mothers. Sample sizes in quantitative studies ranged from 114 to 122,351 pregnant women, most often recruited during ANC visits. The quantitative studies were all cross-sectional except one from Indonesia, which was longitudinal [ 25 ]. Most quantitative studies used logistic regression models to determine the association between potential barriers and the outcome of interest.
The barriers and facilitators identified in the included articles are presented based on the categories of the Andersen’s conceptual model ( Table 3 and Fig 2 ).
Citation | Date | Country | Diseases | Predisposing characteristics | Enabling factors | Need factors |
---|---|---|---|---|---|---|
Bharucha [ ] | 2005 | India | HIV | Facilitators: • Being older • Living closer to the hospital | Barriers: • Being too far along in the birth delivery process when the opportunity to test arises Facilitators: • Having had antenatal care in the hospital rather than in other health facilities | |
Dinh [ ] | 2005 | Vietnam | HIV | Barriers: • Being a housewife • Low level of education | Barriers: • Fear of husband’s disapproval • Perception of poor healthcare availability | Barriers: • Low-risk perception |
Lee [ ] | 2005 | Hong Kong | HIV | Facilitators: • High level of education • Good HIV knowledge • Access to HIV information by means of posters, pamphlets, videos and group talks | Facilitators: • Healthcare workers’ recommendations to be screened | Barriers: • No or low-risk perception Facilitators: • Good perceived benefits of screening |
Rogers [ ] | 2006 | India | HIV | Barriers: • Low knowledge of HIV | Barriers: • Fear of negative reactions from husbands, parents, and community • Fear of stigma and discrimination | |
Munkhuu [ ] | 2006 | Mongolia | Syphilis | Barriers: • Low knowledge of syphilis • Being poor • Long travel distance to get tested | Barriers: • Limited time for screening due to antenatal visits starting late in pregnancy • Complexity of testing service system • Undersupplied screening materials • Healthcare workers not in favour of screening | Barriers: • Reporting previous sexually transmitted diseases |
Kakimoto [ ] | 2007 | Cambodia | HIV | Facilitators: • Basic knowledge of HIV transmission • High partner education level | Barriers: • Need to obtain husband’s approval to be tested | |
Sinha [ ] | 2008 | India | HIV | Barriers: • Low awareness of existing HIV testing facilities | Barriers: • Never received HIV counselling before | |
Todd [ ] | 2008 | Afghanistan | HIV, syphilis, hepatitis B | Facilitators: • High acceptance of screening by providers Barriers: • Providers’ perceptions that infections were rare • Provider’s low perceived likelihood of infection based on healthy appearance • Stigma toward infected individuals • Need to obtain husband’s approval to be tested | ||
Nguyen [ ] | 2010 | Vietnam | HIV | Barriers: • High distance to the hospital | ||
Sasaki [ ] | 2010 | Cambodia | HIV | Barriers: • Low knowledge of HIV | Barriers: • Lack of access to antenatal care services • Need to obtain husband’s approval to be tested | |
Hạnh [ ] | 2011 | Vietnam | HIV | Facilitators: • First antenatal check-up at primary health facilities rather than at district and provincial health facilities | ||
Pharris [ ] | 2011 | Vietnam | HIV | Facilitators: • Younger age • Residence in a semi-urban area • Higher economic status | Barriers: • Low perception of risk | |
Crozier [ ] | 2013 | Thailand | HIV | Barriers: • Low knowledge of HIV and mother-to-child transmission | Barriers: • Language differences between health worker and pregnant women • Concern about the reactions of health workers • Financial barriers • Costs and time of transportation • Provider’s lack of time to inform women properly • Having only one antenatal check-up • Lack of support from husband | Barriers: • Low perception of risk |
Sarin [ ] | 2013 | India | HIV | Facilitators: • More than six years of education • Good knowledge of HIV | Facilitators: • Discussions with husband about HIV • Seeking antenatal care in government district hospitals and private clinics as opposed to community health centres (not equipped with either HIV counselling or testing facilities) | |
Li [ ] | 2014 | China | HIV | Facilitators: • Good knowledge of HIV | Facilitators: • Less perception of social stigma | Facilitators: • High perception of risk |
Khuu [ ] | 2018 | Vietnam | HIV | Barriers: • Younger than 30 years old • Nine or fewer years of education • Working as a homemaker or worker/farmer • Living 20km or more from the hospital | Barriers: • Having received antenatal care at private clinic/hospital only | Barriers: • Low perceived benefits of screening |
Chu [ ] | 2019 | Vietnam | HIV | Barriers: • Belonging to ethnic minorities • Having primary or less education • Being poor • Living in rural areas | ||
Lubis [ ] | 2019 | Indonesia | HIV | Facilitators: • Free HIV screening • Reward and punishment system to motivate providers • Training for health workers Barriers: • Fear of stigma • Limited voluntary counselling and testing opening hours do not cater for those in employment • Not a one-roof for ANC and VCT services • Providers disguising or not revealing purpose of the blood testing for fear of causing offense | ||
Wulandari [ ] | 2019 | Indonesia | HIV | Facilitators: • Living in urban area | ||
Baker [ ] | 2020 | Indonesia | HIV, syphilis | Barriers: • National policy on testing not widely disseminated • Testing not seen as a priority intervention • Multiple small-scale funding sources • Tests seen as expensive by pregnant women • Lack of knowledge and training of providers • Shortage of laboratory personnel • Shortage of tests and laboratory resources • Stigma amongst providers and community • Lack of time from pregnant women • Fear of the results | Barriers: • Perceived low prevalence | |
Pakki [ ] | 2020 | Indonesia | HIV | Facilitators: • Health workers training on predisposing factors of provider-initiated testing and counselling of HIV | ||
Setiyawati [ ] | 2021 | Indonesia | HIV | Barriers: • Pregnant women’s beliefs that their husbands have a bad attitude towards HIV testing | Barriers: • Low perceived benefits of screening | |
Sharma [ ] | 2022 | India | HIV | Barriers: • Low educational level • Low knowledge of HIV • Being poor • Living in rural area • Low exposure to mass media |
Several predisposing characteristics were reported as either barriers or facilitators to antenatal screening for HIV and syphilis. In three studies conducted in Vietnam and India, age was associated with antenatal screening of HIV [ 22 , 32 , 33 ]. Pharris et al. [ 32 ] found that younger Vietnamese women were more likely to be screened while Bharucha et al. [ 33 ] found the opposite result in India. Khuu et al. [ 22 ] identified being younger than 30 years old as a barrier to antenatal screening.
Low education status of pregnant women was a barrier to antenatal screening in three studies conducted in Vietnam [ 22 , 23 , 29 ] and one in India [ 28 ]. Similarly, one study conducted in Hong Kong [ 39 ] and one in India [ 36 ] identified higher education as a facilitator to antenatal screening. However, the level of education associated with a positive likelihood of being screened varied between studies. For example, Khuu et al. [ 22 ] showed that nine or more years of education was associated with more acceptance of screening in Vietnam, whereas Sarin et al. [ 36 ] showed that this was true at more than six years of education in rural India.
Pregnant women’s knowledge about HIV and PMTCT was associated with antenatal screening decisions. Lack of knowledge about HIV amongst pregnant women [ 28 , 34 , 36 , 38 ], about the MTCT services [ 34 ], and about the availability of HIV testing facilities [ 35 ] were identified as barriers to screening in four studies in India, one in Cambodia and one in Thailand. Similarly, three studies conducted in Cambodia, Hong Kong and China found that a better knowledge of HIV amongst pregnant women was associated with a higher screening uptake [ 37 , 39 , 41 ]. Moreover, Munkhuu et al. [ 19 ] found similar results for syphilis in their study conducted in Mongolia. Lack of knowledge about syphilis amongst pregnant women was associated with lower screening uptake. A study conducted in India [ 28 ] found that low exposure to mass media was associated with lower HIV screening uptake. Similarly in Hong Kong, Lee et al. [ 39 ] identified access to HIV information by means of posters, pamphlets, videos, and group talks as a facilitator to screening.
The role of enabling factors such as wealth, place of residence, husbands and health workers’ roles, social and cultural norms or screening cost has been discussed in several articles.
Low household wealth or socio-economic status was a barrier even in countries where antenatal screening was free of charge. Three studies conducted in Mongolia, Vietnam, and India found low socio-economic status as being a barrier to antenatal screening for HIV [ 19 , 23 , 28 ]. Pharris et al. [ 32 ] identified higher economic status as a facilitator to antenatal screening for HIV in Vietnam.
Various studies have shown that the place of residence was associated with antenatal screening for HIV [ 22 , 23 , 25 , 28 , 30 , 32 , 33 ] and syphilis [ 19 ]. A study conducted in Vietnam [ 23 ] and another conducted in India [ 28 ] identified living in a rural area as a barrier to antenatal screening for HIV. Similarly, Wulandari et al. [ 25 ] and Pharris et al. [ 32 ] found that living in an urban area and a semi-urban area were facilitators to antenatal screening of HIV in Vietnam and Indonesia respectively. Proximity to the hospital is also a factor influencing antenatal screening uptake. Khuu et al. [ 22 ] and Nguyen, Christoffersen, and Rasch [ 30 ] found that living further away from the hospital (over 20km in the case of Khuu et al.) was a barrier to antenatal screening for HIV. Similar results were found by Munkhuu et al. [ 19 ] in Mongolia for the antenatal screening of syphilis. Meanwhile, Bharucha et al. [ 33 ] identified living closer to the hospital as a facilitator for antenatal screening of HIV in India.
Two studies conducted in Vietnam found a significant effect of occupation on the decision to be tested. For example, housewives, or labourers/farmers were less likely to be tested for HIV [ 22 , 29 ]. Kakimoto et al. [ 37 ] identified high partner education level as a facilitator to antenatal screening in Cambodia. Meanwhile, Chu, Vo [ 23 ] found a negative association between belonging to ethnic minorities and being tested during pregnancy.
Several articles identified that their husband play a key role in women’s decision to be screened. Fear of negative reactions from their husbands [ 34 ], husband’s disapproval [ 29 ] and lack of support [ 40 ], and beliefs that their husbands have a bad attitude towards HIV testing [ 27 ] were identified as barriers to screening in India, Thailand, Indonesia and Vietnam respectively. Two studies conducted in Cambodia [ 37 , 38 ] found that the perceived need to obtain partner’s authorisation is a barrier to screening for HIV. Similar findings were found in Afghanistan by Todd et al. [ 21 ] for antenatal screening of syphilis and hepatitis B. Similarly, Sarin et al. [ 36 ] reported that having discussions with spouses about HIV in India encouraged women’s screening for HIV.
Various studies have shown that social and cultural factors were key barriers to antenatal screening for HIV, syphilis or hepatitis B. Todd et al. [ 21 ] identified stigma toward infected people as a barrier to antenatal screening for HIV, syphilis, and hepatitis B in Afghanistan. Similar results were found by Baker et al. [ 20 ] in Indonesia for the screening of HIV and syphilis, and Lubis et al. [ 24 ] and Rogers et al. [ 34 ] for the screening of HIV. This last article also identified the fear of negative reactions from parents and community as a barrier. Similarly, Li et al. [ 41 ] found that lower perception of social stigma was associated with higher screening uptake.
Time was also associated with antenatal screening decisions for HIV and syphilis. It was a barrier both from the supply and the demand side. Working pregnant women reported that limited opening hours of screening centres were a major health-facility related barrier to antenatal screening for HIV in Indonesia [ 24 ]. Limited time to inform women properly about HIV during pregnancy and antenatal screening [ 40 ] as well as limited time to perform screening for syphilis [ 19 ] were barriers to antenatal screening in Thailand and Mongolia. From the demand side, long travel time to access antenatal screening services was associated with lower HIV screening uptake in Thailand [ 40 ]. Similarly, lack of time was identified as a barrier to screening for HIV and syphilis in Indonesia by Baker et al. [ 20 ]. Meanwhile, Bharucha et al. [ 33 ] found that being offered testing too late in pregnancy as associated with lower screening uptake for HIV.
The type of screening provider was a factor associated with screening in various studies. Hạnh, Gammeltoft, and Rasch [ 31 ] showed that, in Vietnam, having the first antenatal check-up at a commune health station was a factor associated with an increased probability of being tested, compared with district and provincial health facilities. Similarly and in the same country, having received ANC only at a private clinic/hospital was found to be a barrier [ 22 ]. However, in India, Sarin et al. [ 36 ] found that seeking ANC at government district hospitals and private clinics, as opposed to community health centres not equipped with either HIV counselling or testing facilities, had a positive effect on the probability of receiving HIV screening. Similar results were found by Bharuch et al. [ 33 ] in India. Some facilities lack screening materials and this was associated with lower screening of syphilis in Mongolia [ 19 ] and lower screening of HIV and syphilis in Indonesia [ 20 ]. In addition, a study carried out in Indonesia [ 24 ] revealed that the lack of antenatal care and screening services in the same building was a barrier to HIV screening. In Cambodia, the lack of access to ANC services outside the capital city was a barrier to screening for HIV [ 38 ].
Healthcare workers play a key role in screening decisions. In Vietnam, Dinh, Detels and Nguyen [ 29 ] found that a poor perception of healthcare availability was negatively associated with screening for HIV. Fear that healthcare workers would become impatient with them or that their questions would not be considered important was a barrier in Thailand [ 40 ], and concern that healthcare workers were opposed to antenatal screening for syphilis impeded testing in Mongolia [ 19 ]. Similarly, Lee et al. [ 39 ] identified health worker recommending HIV testing as a facilitator of screening. A study conducted in Vietnam [ 32 ] identified never having received antenatal HIV counselling as a barrier to screening and another identified a language barrier between health workers and women as barriers [ 40 ]. High acceptance of screening for HIV, syphilis and hepatitis B was also a factor increasing screening uptake in Afghanistan [ 21 ]. Pakki et al. [ 26 ] and Lubis et al. [ 24 ] found that, in Indonesia, health worker training as well as reward and punishment system to motivate them was associated with higher antenatal HIV screening. This is consistent with findings reported in Indonesia for HIV and syphilis screening [ 20 ]. Todd et al. [ 21 ] found that provider perceptions of low infection rates and assumptions on a person’s likelihood of infection based on a healthy appearance were associated with lower screening uptake of HIV, syphilis and hepatitis B in Afghanistan. Baker et al. [ 20 ] also identified shortage of laboratory personnel as a barrier to screening.
Costs of screening was also identified as factor influencing HIV and syphilis screening uptake. Tests being seen as expensive by pregnant women was identified as a barrier to HIV and syphilis screening in Indonesia [ 20 ]. Similarly, Crozier et al. [ 40 ] found that costs of screening and transportation represent barriers to screening of HIV and syphilis in Thailand.
At the national-level, enabling factors were identified by two studies in Mongolia and Indonesia [ 19 , 20 ]. Munkhuu et al. [ 19 ] identified the complexity of the syphilis testing service system as a barrier to antenatal screening. Similarly, Baker et al. [ 20 ] found that poor dissemination of national policy on screening, not seeing screening as a priority intervention, and funding consisting of multiple small-scale sources were barriers to HIV and syphilis screening in Indonesia.
Finally, Crozier, Chotiga et Pfeil [ 40 ] showed that having only one ANC check-up was associated with low screening uptake.
Few need factors were identified as barriers or facilitators in antenatal screening for HIV and syphilis. Four studies conducted in Hong Kong, Vietnam and Thailand found that low perceived risk of HIV was associated with low screening [ 29 , 32 , 39 , 40 ]. Similarly, Lee, Yang, and Kong [ 41 ] found that, in China, high perceived risk of HIV was associated with high screening. In a study investigating barriers and facilitators in the delivery of antenatal testing for anaemia, HIV, and syphilis, Baker et al. [ 20 ] identified perceived low prevalence of HIV and syphilis as barriers to antenatal screening in Indonesia. Two studies found that believing that HIV testing was not important during pregnancy was associated with a lower screening uptake in Indonesia and Vietnam [ 22 , 27 ]. Similar Lee et al. [ 39 ] identified the perception of the benefits of HIV screening as a factor facilitating it. Finally, Munkhuu et al. [ 19 ] found that women who previously reported STIs were less likely to be screened in Mongolia.
This study is the first to provide a narrative synthesis of the current literature on barriers and facilitators to antenatal screening for HIV, syphilis and hepatitis B in Asia. This systematic review of qualitative, quantitative and mixed-method studies shows that there are research gaps into the factors influencing screening for syphilis and hepatitis B, with most of the studies reviewed focusing on HIV. This review therefore effectively allows conclusions to be drawn about HIV alone.
Antenatal screening for HIV in Asia is influenced by a range of factors including predisposing characteristics (age, education level, wealth, place of residence, knowledge about HIV), enabling factors (husband support, health facilities characteristics, health workers’ support and training) and need factors (risk perception, perceived benefits of screening). These factors are similar to those identified in a review conducted by Blackstone et al. [ 12 ] in sub-Saharan Africa. In our literature review, as in the sub-Saharan African context, being better-off and highly educated were identified as facilitators. In both contexts, pregnant women’s lack of knowledge about HIV appears to be a significant barrier to antenatal HIV screening. Our results suggest that antenatal screening could be improved by facilitating access to information for women, their husbands and health workers. Most studies have emphasised the importance of improving dissemination of information about HIV and HIV testing in order to improve uptake of antenatal screening. Unlike Blackstone et al.’s review of the literature in the sub-Saharan African context [ 12 ], our review did not identify fear of results as such as a barrier to testing, but more broadly fear of partner reactions and potential violence in the event of a positive result. We did not find that cultural gender norms to be barrier, such as "testing is a woman’s business", as found by Blackstone et al. [ 12 ]. However, women in this review mentioned the need to obtain a husband’s approval to undergo screening. In both African and Asian contexts, societal stigma towards HIV-positive people proved to be a major barrier to HIV testing. Our findings, and those of Blackstone et al. [ 12 ], suggest that antenatal screening could be improved by strengthening the health care system. Both reviews highlighted the role of healthcare and communication professionals in increasing antenatal screening rates. In the sub-Saharan African context the perception of screening being mandatory was a barrier to screening, but this did not emerge in our literature review.
Although the studies we reviewed were all conducted in Asia, they spanned very different contexts. It is reasonable to assume that the barriers to antenatal screening will differ between Hong Kong and India for instance. Guidelines about screening and adherence to guidelines differ between countries. A review of maternal health care policies in eight countries in the Western Pacific region [ 42 ] found that WHO recommendations on antenatal HIV screening were not included in antenatal care guidelines in two countries. In 2018, 37 countries in the Asia Pacific region promoted antiretroviral therapy for all pregnant and breastfeeding women living with HIV, but in six of these countries, the policy is being implemented in less than 50% of all maternal and child health sites [ 43 ]. Reported barriers in the Hong Kong study were mainly focused on the demand side [ 39 ], whereas the Mongolia study identified many supply-side barriers [ 19 ]. This highlights the need for qualitative studies in Asian contexts to investigate context-dependent factors that may be missed in quantitative studies.
As stigmatisation of people with STDs is one of the main factors preventing pregnant women from being screened, interventions should provide information and counselling to pregnant women and their husbands, tailored to low-literacy populations to help reduce stigma and increase uptake [ 36 , 38 , 39 ]. Raising awareness within communities of the importance of male partner involvement, the benefits of screening and adherence to treatment could increase demand for antenatal screening services. However, studies on awareness campaigns about HIV in Vietnam [ 44 ] and Thailand [ 45 ] showed that the stigma attached to social judgement is difficult to reduce. Various studies recommended the integration of HIV screening into community level ANC services [ 23 , 25 , 30 , 31 , 39 ] and the development of opt-out approaches for those who prefer not to test [ 29 , 35 ], as recommended in sub-Saharan Africa by Blackstone et al. [ 12 ]. We found that husbands play a key role in encouraging pregnant women to undergo screening. Interventions to improve husbands’ knowledge and involvement in maternal and newborn health had a positive impact on maternal health behaviour in Bangladesh [ 46 ] and Nepal [ 47 ]. To reduce social and financial barriers to antenatal screening, screening should be offered to pregnant women universally free of cost [ 32 , 39 ]. Currently, national budgets do not cover all the costs associated with antenatal screening in all Asian countries. In the 17 Asian countries for which data on the cost of screening pregnant women for HIV, syphilis and hepatitis B were available in 2017, HIV screening of pregnant women was free in all of these countries, syphilis screening in 14 countries and hepatitis B screening was free in eight countries [ 11 ]. Finally, the quality of services depends on the availability and capacity of healthcare workers. To reduce the persistence of inappropriate healthcare practices in pregnancy, interventions need to develop health worker training programmes on STIs and pregnancy screening. A successful initiative in Cambodia in decreasing risky sexual intercourse and improving the access to sexual and reproductive health care services has focused on training community health workers in sexual and reproductive, maternal, neonatal, child and adolescent health [ 48 ].
Adolescent pregnancy is still common in the region with 3.7 million births to adolescent girls aged 15–19 every year in Asia and the Pacific [ 49 ]. Pregnant adolescents are very vulnerable and are known to have poor outcomes for both mother and child [ 50 ]. This systematic review of the literature highlighted a lack of age-specific data, particularly in relation to adolescent pregnancy, and confirmed the need to fill this research gap. Similarly, a systematic literature review of interventions addressing health outcomes for pregnant adolescents in low- and middle-income countries highlighted the need to develop studies to design high-quality care and services for pregnant adolescents [ 51 ].
Several limitations to this study should be noted. Firstly, most studies sampled pregnant women through ANC services. However, women who have not sought ANC may face the greatest barriers to testing. Due to resource constraints, only articles in English were reviewed, which may limit access to the grey literature and studies published in other languages (especially Chinese). Finally, different studies were undertaken in different contexts and using different methods. This heterogeneity limits our ability to compare between studies. However, this systematic review follows a rigorous method of article selection and analysis. It complements existing literature reviews on barriers to antenatal screening, particularly in sub-Saharan Africa [ 12 , 52 ].
The main barriers to antenatal screening in this systematic review were stigmatisation of infected individuals, lack of involvement of husbands and healthcare system factors. To improve uptake of antenatal screening interventions to improve community and husband involvement, awareness campaigns with communities and health workers, and training of health workers on STI issues are needed. While countries vary in their contexts and implementation of international recommendations on integrated antenatal screening for STIs, in all settings the planning, implementation, reporting and monitoring of interventions to eliminate mother-to-child transmission require coordination between different health system stakeholders at national, regional and local levels to avoid gaps or duplication. Global, regional and national guidelines need to be harmonised to avoid gaps and duplication between disease-specific and maternal and child health programs and guidelines. Integration of services for different diseases should be prioritised where possible. However, studies to examine the barriers and facilitators to antenatal screening for syphilis and hepatitis B and to examine the behavioural determinants of antenatal screening in Asia are still needed.
Funding statement.
The authors received no specific funding for this work.
19 May 2023
PONE-D-23-03027Barriers and facilitators to antenatal screening for sexually transmitted diseases in Asia: a scoping review.PLOS ONE
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Reviewer #1: No
Reviewer #2: No
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Reviewer #1: N/A
Reviewer #2: N/A
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Reviewer #1: Yes
Reviewer #2: Yes
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Reviewer #1: The topic is of great interest, however the manuscript seems hurriedly put together. Concepts involved such as Andersen's model are not clearly and coherently applied in the course of the write-up.
The title for example does not capture the full essence of the review - it seems to be based on the "regional framework for the triple elimination of MTCT of HIV, Hep B and syphillis in Asia and Pacific" (lines 99 - 101)- that should have reflected clearly in the title. Such an understanding should have been provided briefly in the "Background" section of the script.
Secondly, the target population of the review was not clear right from the "title". Who did the review focus on - pregnant women, healthcare providers, relatives, etc. or all of them? That is not clear from the manuscript.
The objectives of the review as stated in lines 74 and 75 are not meant for a scoping review, but some other approaches that would generate clear evidence such as a review of qualitative evidence.
The methods section has lots of lapses.
a. A key concept such as the "population of the review" is not defined. The "search strategy" should have been systematically presented - e.g., keywords/ subject headings/ index terms that were used, example of a search strategy of at least one of the databases should have been placed in the appendices; the search should have been as exhaustive as possible - searching two databases does not sound exhaustive enough.
b. The "inclusion and exclusion criteria" should have been clearly defined each criterion - this subsection at best is confusing to the reader as it does not serve its purpose of clearly pointing out how studies were included in the review. Studies of experimental designs were excluded with no apparent reasons as to why they were.
c. Under "Data extraction", the Andersen's framework was said to have been the guide - it would have been great to have this clearly "tabulated" with "findings" related to each component of the framework duely and systematically presented. The quality of studies was assessed, but this outcome did not feature further into any decision-making or discussion as to how study quality influenced the review process.
d. Andersen's model as defined in lines 123 - 124 does not seem to be in sync with the cited publication (11), i.e., predisposing, enabling, and needs factors. "Enabling factors" were not given the prominence required.
Aside the mention of "facilitators" on line 147, this key component of the review was hardly addressed. Furthermore in the results section, the nature of the findings as were presented did not necessarily aptly fit the defined factors under the Andersen model.
In its current form, this manuscript in my view is not fit for publication.
Reviewer #2: Review Comments on manuscript PONE-D-23-03027
…..perhaps the title should be restricted to HIV, Syphilis and Hepatitis B rather than ‘sexually transmitted diseases’
Despite being a scoping review, a little more detail will improve the Background and situate arguments in better context.
• Lines 50/51…….the authors can provide recent data on the morbidity and mortality they refer to…..first globally and in the Asian context
Quantify the prevalence of these STDs in Asia (at least present data from some Asian countries)
• Lines 58/61…..can the authors assign, at least, an estimate of how many children are born to these STDs? Can they quantify antenatal screening for STDs in Asia? Can they give us an idea of how low is ‘low’.
I think it would be useful to give a brief overview of this WHO regional framework and what different prescriptions it gave compared to whatever existed before its formation
• Lines 68/70……The authors may want to give more meaning to the listed ‘barriers’ and how they relate to uptake of HIV screening services.
It would be particularly interesting to see what the story is for “health system and health care provider issues”
In many jurisdictions in sub-Saharan Africa, HIV screening is part of the antenatal care package and is offered using the opt-out model.
• There is no literature review summarising the research-based evidence on barriers and facilitators to antenatal screening for STDs in the Asian context.
Why is the statement above a problem? What is the burden of maternal and child morbidity and mortality in Asia in the context of HIV, Syphilis, Hepatitis C? What are the fall-outs from the supposed low uptake of available screening services? What do we stand to lose if this review is not done to better understand barriers and facilitators that can help inform useful interventions?
• Can the authors rewrite the Methods section without ‘We’?
• Line 84. We used a very inclusive search strategy to ensure that no item was missed…..Can you give a 100% guarantee no item was missed?
• There appears to be something in Line 92 that is not supposed to be there
Inclusion and Exclusion Criteria
The inclusion and exclusion criteria appear to be ‘all over the place’. They can be made more focused.
We did not include studies investigating antenatal screening for other STDs……..This does not qualify as an exclusion criterion because you have earlier specified that you are dealing with HIV, Hep B and Syphilis
• The data extraction sub-section has nothing on “facilitators”
• Line 121…..the authors may want to justify the choice of Andersen’s conceptual model over other models they could have used.
• For Table 1, I think the year the study was conducted ought to be in separate column by itself. This will enable readers to relate them to implementation of the MDGs and contextualize them.
• I have some questions relating to Fig.1;
……you mentioned Google Scholar but I don’t see in the flow diagram
…….I am struggling to understand how you excluded 546 articles because the studies were not conducted in Asia when ‘Asia’ should have been a key part of your search strategy. Kindly elaborate on how this happened.
• Lines 210/211…….please give more meaning to ‘perceptions of poor healthcare support’ and ‘concerns about the reactions of healthcare workers
Secondly, of the 16 articles, 15 were on HIV and 1 was on Syphilis with nothing on Hepatitis B. In this context, I fail to see how you can make any reasonable pronouncements on Syphilis and Hepatitis B screening uptake.
On this basis, I suggest you drop off Syphilis and Hep B and make your work entirely about uptake of HIV screening than about STDs and appropriately reorient your discussion to that effect.
I look forward to reading a new version of your work.
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Reviewer #1: Yes: Yeetey ENUAMEH
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Dear Doctor Ampofo,
We thank you and the reviewer for your time and generous comments provided on our manuscript PLONE-D-23-03027 entitled "Barriers and facilitators to antenatal screening for sexually transmitted diseases in Asia: a scoping review", and we thank you for the opportunity to address these comments. After consideration of your comments, we have made several improvements.
The comments provided are shown in bold below, with our responses in italics.
Editor's Comments to the Author:
1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming.
Response: We have ensured that the manuscript meets the stylistic requirements of PLOS ONE.
2. Please include a copy of Tables 4 and 5 which you refer to in your text on page 6.
Response: A copy of tables 4 and 5 has been included under the name S2 Table and S3 Table.
3. Please include captions for your Supporting Information files at the end of your manuscript, and update any in-text citations to match accordingly.
Response: Captions for our Supporting Information files have been included at the end of the manuscript.
Reviewers’ Comments to the Author:
Reviewer #1:
The topic is of great interest, however the manuscript seems hurriedly put together. Concepts involved such as Andersen's model are not clearly and coherently applied in the course of the write-up.
Response: Thank you for your comment. We now define Andersen’s model (lines 148-153) and clearly and systematically apply the concepts cited. We have added Table 3 and systematically structured our results according to each component of Andersen’s model. The "facilitators" have been taken into account appropriately in the review.
The title for example does not capture the full essence of the review - it seems to be based on the "regional framework for the triple elimination of MTCT of HIV, Hep B and syphilis in Asia and Pacific" (lines 99 - 101)- that should have reflected clearly in the title. Such an understanding should have been provided briefly in the "Background" section of the script.
Response: We have changed the initial title from “Barriers and facilitators to antenatal screening for sexually transmitted diseases in Asia: a scoping review” to “A systematic review of barriers and facilitators to antenatal screening for HIV, syphilis or hepatitis B in Asia: perspectives of pregnant women, their relatives and health care providers.” The role of the WHO framework as the basis for this study has also been clarified in the background section (lines 76-89).
Response: On the basis of all the reviewers' comments, we decided to carry out a systematic analysis of the literature rather than a scoping review, using a second person to screen and review articles in duplicate and by searching other databases. We adapted the objectives to those of a systematic literature review (lines 113-115).
a. A key concept such as the "population of the review" is not defined. The "search strategy" should have been systematically presented - e.g., keywords/ subject headings/ index terms that were used, an example of a search strategy of at least one of the databases should have been placed in the appendices; the search should have been as exhaustive as possible - searching two databases does not sound exhaustive enough.
Response: Thank you for this comment. To make the search as exhaustive as possible and in line with other reviews of this nature, we searched Ovid (MEDLINE, Embase, PsycINFO), Scopus, Global Index Medicus and Web of Science. Our database search strategy has been included in S1 File.
Response: The eligibility criteria for the inclusion of studies have been rewritten and tabulated in Table 2 using the acronym SPlDER: S sample; P phenomenon of interest; D design; E evaluation; R research type. Our original inclusion/exclusion criteria were unchanged except that we also decided to include experimental design studies.
c. Under "Data extraction", the Andersen's framework was said to have been the guide - it would have been great to have this clearly "tabulated" with "findings" related to each component of the framework duly and systematically presented. The quality of studies was assessed, but this outcome did not feature further into any decision-making or discussion as to how study quality influenced the review process.
Response: We agree that a more systematic application of Andersen’s framework improves the paper so have rewritten the results section to clearly reflect each of the elements of the Andersen framework and added Table 3. As the aim of the review was to describe and synthesise a body of literature and not to determine effect size, we did not exclude studies on the basis of their quality assessment (lines 160-161) but we have summarised the quality assessment in S2 and S3 Tables to enable readers to see the quality of the evidence included in the review.
Response: We agree with this comment and have now given more explanation of the ‘enabling factors’ of antenatal screening (lines 151-152).
Response: As explained above we have now explicitly defined the "facilitators" in Table 1 and entirely rewritten the results section to follow the factors defined in Andersen’s model.
Response: Thank you for your detailed comments. We hope that the changes you have made will enable the study to be published.
Reviewer #2:
Title…..perhaps the title should be restricted to HIV, Syphilis and Hepatitis B rather than ‘sexually transmitted diseases’.
Response: Thank you. We have changed the title to “A systematic review of barriers and facilitators to antenatal screening for HIV, syphilis or hepatitis B in Asia: perspectives of pregnant women, their relatives and health care providers.”
Introduction: Despite being a scoping review, a little more detail will improve the Background and situate arguments in better context.
Response: We have expanded the introduction to better place the study in context. We have also changed from a scoping to a systematic review.
Lines 50/51…….the authors can provide recent data on the morbidity and mortality they refer to…..first globally and in the Asian context Quantify the prevalence of these STDs in Asia (at least present data from some Asian countries).
Response: Data on mother-to-child transmission of HIV, syphilis and hepatitis B were added to the introduction. The prevalence of the STDs considered was quantified in the introduction section.
Lines 58/61…..can the authors assign, at least, an estimate of how many children are born to these STDs? Can they quantify antenatal screening for STDs in Asia? Can they give us an idea of how low is ‘low’.
Response: We have added an estimate of the number of children born with these STDs (lines 54-59), as well as a quantification of antenatal screening for STDs in Asia (lines 63-68).
Response: Thank you for this suggestion. We have added an overview of the WHO regional framework and its main prescriptions (lines 76-87).
Lines 68/70……The authors may want to give more meaning to the listed ‘barriers’ and how they relate to uptake of HIV screening services. It would be particularly interesting to see what the story is for “health system and health care provider issues”. In many jurisdictions in sub-Saharan Africa, HIV screening is part of the antenatal care package and is offered using the opt-out model.
Response: Thank you for this suggestion. The obstacles listed have been detailed for greater clarity.
There is no literature review summarising the research-based evidence on barriers and facilitators to antenatal screening for STDs in the Asian context. Why is the statement above a problem? What is the burden of maternal and child morbidity and mortality in Asia in the context of HIV, Syphilis, Hepatitis C? What are the fall-outs from the supposed low uptake of available screening services? What do we stand to lose if this review is not done to better understand barriers and facilitators that can help inform useful interventions?
Response: We have clarified and expanded the introduction by highlighting the importance of this review (lines 88-92) and giving the reasons why a literature review in Asia is needed (lines 102-112). We now detail, in the introduction, the burden of maternal and infant morbidity and mortality in Asia within the limits of available data. We have also explained the consequences of the low uptake of screening services (lines 70-75).
Can the authors rewrite the Methods section without ‘We’?
Response: We decided to keep this section written in active voice as it is easier to understand and saves words. It is nowadays recommended for scientific writing in biomedical journals.
Line 84. We used a very inclusive search strategy to ensure that no item was missed…..Can you give a 100% guarantee no item was missed?
Response: We removed this sentence from the manuscript.
There appears to be something in Line 92 that is not supposed to be there.
Response: We removed this from the manuscript.
Inclusion and Exclusion Criteria: The inclusion and exclusion criteria appear to be ‘all over the place’. They can be made more focused. We did not include studies investigating antenatal screening for other STDs……..This does not qualify as an exclusion criterion because you have earlier specified that you are dealing with HIV, Hep B and Syphilis.
Response: We agree and have rewritten the eligibility criteria for study inclusion using the acronym SPlDER: S sample; P phenomenon of interest; D design; E evaluation; R research type.
The data extraction sub-section has nothing on “facilitators”
Response: In the methods, we have added a subsection on the extraction of data and explained how we focus upon both barriers and facilitators to antenatal screening within the structure of Andersen’s framework (Table 3).
Line 121…..the authors may want to justify the choice of Andersen’s conceptual model over other models they could have used.
Response: Thank you for your suggestion. We chose the Andersen conceptual model because it provides an understanding of how individuals and environmental factors influence health behaviours. This theoretical framework is widely used in literature reviews on healthcare utilisation. This has been justified in lines 147-150.
For Table 1, I think the year the study was conducted ought to be in separate column by itself. This will enable readers to relate them to implementation of the MDGs and contextualize them.
Responses: We agree with this suggestion and a separate column for the date has been added to Table 1.
I have some questions relating to Fig.1;
Responses: We have modified Figure 1 to reflect the new search strategy. With the new search strategy, only four articles were found to have been conducted outside Asia because the term "Asia" appeared in their abstracts.
Lines 210/211…….please give more meaning to ‘perceptions of poor healthcare support’ and ‘concerns about the reactions of healthcare workers
Response: We agree and have clarified the “perception of poor healthcare support” and the “concerns about the reactions of healthcare workers” (lines 276-291).
Secondly, of the 16 articles, 15 were on HIV and 1 was on Syphilis with nothing on Hepatitis B. In this context, I fail to see how you can make any reasonable pronouncements on Syphilis and Hepatitis B screening uptake. On this basis, I suggest you drop off Syphilis and Hep B and make your work entirely about the uptake of HIV screening than about STDs and appropriately reorient your discussion to that effect.
Response: We agree with your suggestion with respect to the discussion and conclusions and have rewritten these sections with respect to HIV only. However, the new search showed up three papers on syphilis and one on hepatitis B, so we believe it is important to highlight this gap and summarise the limited evidence in the results.
We hope that you will be satisfied with the amendments made. If there are any further issues do not hesitate to get in touch. We would like to thank you again for your time and consideration of our manuscript.
Yours sincerely,
Lucie Sabin (on behalf of all co-authors)
Submitted filename: response_reviewers.docx
PONE-D-23-03027R1A systematic review of barriers and facilitators to antenatal screening for HIV, syphilis or hepatitis B in Asia: perspectives of pregnant women, their relatives and health care providers.PLOS ONE
Dear Dr. Sabin, Thank you for resubmitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. The manuscript was sent for further review - an initial reviewer advised minor revisions (not accept) and a third (new) reviewer has indicated major revision. The original second reviewer was not available for re-review. You have the benefit then of three careful reviews. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.
Please submit your revised manuscript by Feb 16 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at gro.solp@enosolp . When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.
Stephen Michael Graham, FRACP, PhD
Additional Editor Comments:
This submission was reviewed for a second time - and again a decision of Major Revision has been made. If you decide to resubmit, then there will need to be clear evidence that you have addressed all concerns of the reviewers for it to be considered for re-review - and then further review will be required anyway.
1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.
Reviewer #2: (No Response)
Reviewer #3: (No Response)
2. Is the manuscript technically sound, and do the data support the conclusions?
Reviewer #2: Partly
Reviewer #3: Yes
3. Has the statistical analysis been performed appropriately and rigorously?
4. Have the authors made all data underlying the findings in their manuscript fully available?
Reviewer #3: No
5. Is the manuscript presented in an intelligible fashion and written in standard English?
6. Review Comments to the Author
Reviewer #2: Comments on manuscript PONE-D-23-03027R1
I am grateful to the authors for incorporating the previous comments made. The manuscript looks more refined now but will still need to be improved in some aspects as listed below.
After they have worked on these comments, I believe the work can be accepted for publication
• Line 21………I am wondering if Antenatal screening alone is enough for PMTCT. Shouldn’t it be accompanied by treatment?
• Line 26…..read it again and rectify the grammatical error there….similar error in Line 30/31
• Line 27……..what you sought for in those published articles should be in this line.
• There is nothing about “barriers” in the Results section. If there is, it needs to be made more explicit
• Line 73/74……can the authors show proof that there is a low uptake of STDs screening?
• Who or which persons conducted the initial search? (show with initials)
• Who is the third reviewer?
• Line 133……what is the use of the boldened Error statement there?
• In SPIDER, you defined SAMPLE to include women of childbearing age. I reckoned this work was about Antenatal Screening of Pregnant women. Please clarify the need to include women of childbearing age.
• Review the Data Extraction section for some grammatical omissions and errors. Line 150 is missing “of”. Line 151 …..’categorizes’ instead of ‘categories’.
• Line 160……’that’ instead of ‘who’
Line 321…..rephrase to read “…….allow conclusions to be drawn effectively about HIV alone”
Line 340/341…….there is free screening of HIV, Hep B and Syphilis in many parts of sub-Saharan Africa already.
Line 348……On heterogeneity……there were 19 quantitative studies and you could have evaluated heterogeneity statistically to enable you make a more refined pronouncement on the subject
The Conclusion can be better written…..with emphasis on what specifically needs to be done and by which organization or department or health agency
Reviewer #3: GENERAL COMMENTS:
This review deals with an important topic that could be very useful in the prevention of HIV, syphilis and hepatitis B and transmission of these infections to infants. However, there are several major limitations to the quality of the review which hinder its relevance and applicability. The initial most striking feature of this review is that all four authors are affiliated with only one institute and this institute is in a high-income country that is not in Asia (used as general term here as the authors do not define Asia in their manuscript). Do any of these authors have lived experience of ANC, or healthy policy or practice in the region they are reviewing? If so, it would be helpful to have this information somewhere. Furthermore, the review only includes manuscripts published in English, a major limitation given the region being considered. there are excellent research Institutes throughout Asia, and no doubt this review would be enhanced if it included some collaborations within Asia to increase available grey literature and other studies that may not have been in their search methods.
DETAILED COMMENTS:
“Despite improvements” is vague, some time reference of stats would be helpful here.
STIs is more commonly used now, rather than STDs.
“Antenatal screening” (Sabin, p. 1)
• and treatment. without treatment, screening won’t prevent transmission.
Methods paragraph. typo ‘conducted’ included twice in 1st and last sentence.
What is the definition of ‘Asia’? This should be included in the abstract.
Results section: please define in predisposing characteristics, enabling factors and need factors who you are referring to. The pregnant woman? The health worker?
INTRODUCTION:
“antenatal screening” (Sabin, p. 12) Line 62. And treatment, screening alone will not prevent transmission.
“infected women may transmit infections to their sexual partners or children” (Sabin, p. 13) Line 71. Please rephrase. Women are often infected by their partner, only saying women may give it to their partners overemphasizes their responsibility. What do you mean by infecting their children? Do you mean by MTCT? If so please be specific.
“Meanwhile, it encourages the participation of women living with HIV” (Sabin, p. 13) Line 86. prevention of MTCT of HIV, syphilis and hepatitis B is a shared responsibility, men and communities should also be encouraged to participate.
Preventing male transmission to women during sex, as well as preventing community transmission, of HIV, Syphilis and Hep B is also an effective method of preventing neonatal and infant infections. Whilst I recognise this is not the focus of the review, it should at least be mentioned to prevent misunderstandings and reduce stigma. Overly focusing on pregnant women being the source of transmission to their infants misses an opportunity to emphasise that they are not always the original source of the infection and may not have been able to negotiate appropriate protection for themselves in order to avoid infection.
“An estimated 10,000 new HIV infections occurred 56 among children aged 0–14 years in the Asia Pacific region in 2017” (Sabin, p. 12) Line 56/57. What is the number of infants infected with HIV due to MTCT? You mentioned 10,000 children infected between 0 and 14 years, but clearly not all of these are necessarily due to MTCT.
Line 122, word repetition.
Research type. Why were the articles limited to English? Given most countries in Asia have a primary language other than English this seems a big problem / barrier to identifying relevant research.
Table 3. It would be helpful to also have a column of disease studied in this table.
Line 208. Whose knowledge are you referring to?
Paragraph re male partner’s opinion. In some countries mentioned it may be impossible for a woman to be screened without the express permission of the husband. It would be useful to contrast findings against legal framework for relevant countries as the approach to overcoming this barrier would be very different.
DISCUSSION:
Line 317. Given this review was limited to the English language I do not agree with it being referred to as a “comprehensive synthesis.”
Terminology used is not consistent regarding if this is a scoping review, narrative review or systematic review.
Paragraph 2. Part of the justification for this review was that findings in Asia may differ from that already published in sub-Saharan Africa. Given this, it would be interesting to understand the similarities and differences in more detail in this paragraph.
Line 330/331. Can you reference other differences in ANC screening or barriers that may support this statement?
Line 336/337. It is likely that training programs already exist, could you please highlight what efforts are already made in these settings before suggesting interventions. Again line 340/341 calls for free screening, this would be more helpful if information regarding whether this does or does not exist in the areas included in studies would be more meaningful.
The limitations paragraph needs to mention the limitation of including only English language and the apparent lack of inclusion of experts from the region.
CONCLUSION:
“and STDs” (Sabin, p. 30) Line 454. Please rephrase, you do not address all sexually transmitted infections.
“systematic review” (Sabin, p. 30) Line 354. Be consistent with use of terms narrative or systematic review.
In terms of translating these findings into practice it would be helpful, if possible, to comment in the conclusion as to which factors appeared to be the largest barriers. It may be that this varies in different countries, or at the sub district level. In addition to reviewing studies that look at implementing screening (and treatment), it would be more helpful to also know/contrast this with which countries have policies for ANC screening and treatment and if this is meant to be free or fee for service.
7. PLOS authors have the option to publish the peer review history of their article ( what does this mean? ). If published, this will include your full peer review and any attached files.
Submitted filename: Review of PONE-D-23-03027_R1.docx
21 Feb 2024
22 Feb 2024
PONE-D-23-03027R2A systematic review of barriers and facilitators to antenatal screening for HIV, syphilis or hepatitis B in Asia: perspectives of pregnant women, their relatives and health care providers.PLOS ONE Dear Dr. Sabin, Thank you for resubmitting your manuscript to PLOS ONE. After careful consideration, we feel that you have addressed comments and suggestions of previous reviewers. I request that you consider comments below about clarity on age ranges and representativeness of the populations studied - if possible.
Please submit your revised manuscript by Apr 07 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at gro.solp@enosolp . When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.
Journal Requirements:
Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.
Thanks for resubmitting and addressing the comments of the reviewers so comprehensively.
I support publication - however, would it be possible to improve the reporting of these populations by age groups that they represent? Is that something that could be added in a specific column in Table for each study: age range OR what proportion were adolescent pregnancy for example.
Adolescent pregnancy is still common in the region and a very vulnerable population with known poorer outcomes for mother and baby. V neglected population and as at risk for such infections as other pregnant women but perhaps even less likely to be screened? There is a data gap.
If this is not possible, it may still be worth a comment in discussion to highlight lack of data by age, especially in this vulnerable group. a suggested ref for this would be Sabet F, et al. The forgotten girls: .....Lancet. 2023;402:1580-1596.
For journal use only: PONEDEC3
29 Feb 2024
Dear Dr Graham,
We thank you and the reviewer for your time and comments provided on our manuscript PLONE-D-23-03027 entitled " A systematic review of barriers and facilitators to antenatal screening for HIV, syphilis or hepatitis B in Asia: perspectives of pregnant women, their relatives and health care providers", and we thank you for the opportunity to address these comments. After consideration of your comments, we have made several improvements.
Response: The list of references has been examined. It is complete and correct, and no changes were required.
Response: Thank you for highlighting the importance of this research gap. Unfortunately, it was not possible to report the proportion of adolescent pregnancies in each study, as this information was not always included in the articles. However, we have added a paragraph in the discussion section on the lack of age-specific data, particularly for this vulnerable group of pregnant women, and the importance of filling this data gap (lines 388 to 394).
A systematic review of barriers and facilitators to antenatal screening for HIV, syphilis or hepatitis B in Asia: perspectives of pregnant women, their relatives and health care providers.
PONE-D-23-03027R3
Dear Dr Sabin,
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APA Abstract Format. The abstract page is the second page of your report, right after the title page. This page is numbered 2 on your report. On the first line of the page, center the word Abstract in bold. (Do not underline, italicize, or otherwise format the title.) On the second line, start your abstract.
Here are the steps we recommend when writing abstracts for literature reviews: Introduce the research topic: Begin by stating the subject of your literature review. Explain its significance and relevance in your field. Provide context that highlights the broader impact and necessity of your review. For example, "This literature review focuses ...
A literature review abstract must also provide information on the design of the work, the procedures used, data analysis, etc. The method section helps the reader understand how the work was done. It enlightens the reader about the strategies used to answer the research questions posed. A literature review abstract is incomplete without this ...
This abstract provides an overview of your research questions, problems, or hypotheses, research methods, study results, conclusions, recommendations, and implications. Literature review abstracts in APA style are common in scholarly journals, offering readers a glimpse into the content of the paper. While the maximum word count for an APA ...
This is why the literature review as a research method is more relevant than ever. Traditional literature reviews often lack thoroughness and rigor and are conducted ad hoc, rather than following a specific methodology. Therefore, questions can be raised about the quality and trustworthiness of these types of reviews.
Writing a Literature Review. A literature review is a document or section of a document that collects key sources on a topic and discusses those sources in conversation with each other (also called synthesis). The lit review is an important genre in many disciplines, not just literature (i.e., the study of works of literature such as novels and ...
Limit your abstract to 250 words. 1. Abstract Content . The abstract addresses the following (usually 1-2 sentences per topic): • key aspects of the literature review • problem under investigation or research question(s) • clearly stated hypothesis or hypotheses • methods used (including brief descriptions of the study design, sample ...
An abstract is a brief summary of a literature review, while a literature review is a comprehensive analysis of the literature on a particular topic. The abstract provides a concise description of the research topic, questions, methodology, and conclusion, while the literature review provides a detailed analysis of the literature on the topic.
Examples of literature reviews. Step 1 - Search for relevant literature. Step 2 - Evaluate and select sources. Step 3 - Identify themes, debates, and gaps. Step 4 - Outline your literature review's structure. Step 5 - Write your literature review.
An abstract should give the reader enough detail to determine if the information in the article meets their research needs...and it should make them want to read more! While an abstract is usually anywhere between 150 - 300 words, it is important to always establish with your teacher the desired length of the abstract you are submitting.
The actual review generally has 5 components: Abstract - An abstract is a summary of your literature review. It is made up of the following parts: A contextual sentence about your motivation behind your research topic. Your thesis statement. A descriptive statement about the types of literature used in the review. Summarize your findings.
Step 2: Methods. Next, indicate the research methods that you used to answer your question. This part should be a straightforward description of what you did in one or two sentences. It is usually written in the past simple tense, as it refers to completed actions.
The best proposals are timely and clearly explain why readers should pay attention to the proposed topic. It is not enough for a review to be a summary of the latest growth in the literature: the ...
An abstract of a report of an empirical study should describe: (1) the problem under investigation (2) the participants with specific characteristics such as age, sex, ethnic group (3) essential features of the study method (4) basic findings (5) conclusions and implications or applications. An abstract for a literature review or meta-analysis should describe: (1) the problem or relations ...
Your report, in addition to detailing the methods, results, etc. of your research, should show how your work relates to others' work. A literature review for a research report is often a revision of the review for a research proposal, which can be a revision of a stand-alone review. Each revision should be a fairly extensive revision.
When searching the literature for pertinent papers and reviews, the usual rules apply: be thorough, use different keywords and database sources (e.g., DBLP, Google Scholar, ISI Proceedings, JSTOR Search, Medline, Scopus, Web of Science), and. look at who has cited past relevant papers and book chapters.
1. Outline and identify the purpose of a literature review. As a first step on how to write a literature review, you must know what the research question or topic is and what shape you want your literature review to take. Ensure you understand the research topic inside out, or else seek clarifications.
A literature review may consist of simply a summary of key sources, but in the social sciences, a literature review usually has an organizational pattern and combines both summary and synthesis, often within specific conceptual categories.A summary is a recap of the important information of the source, but a synthesis is a re-organization, or a reshuffling, of that information in a way that ...
Abstract. Literature reviews establish the foundation of academic inquires. However, in the planning field, we lack rigorous systematic reviews. In this article, through a systematic search on the methodology of literature review, we categorize a typology of literature reviews, discuss steps in conducting a systematic literature review, and ...
Ultimately, an abstract is often a factor in determining whether someone will access a manuscript, attend a conference presentation, or consider an application for funding in full. 3 Researchers undertaking systematic searching and screening for a literature review will use the abstract to determine the relevance of the publication for the ...
Background: There is a small body of research on improving the clarity of abstracts in general that is relevant to improving the clarity of abstracts of systematic reviews. Objectives: To summarize this earlier research and indicate its implications for writing the abstracts of systematic reviews. Method: Literature review with commentary on ...
at each of these in turn.IntroductionThe first part of any literature review is a way of inviting your read. into the topic and orientating them. A good introduction tells the reader what the review is about - its s. pe—and what you are going to cover. It may also specifically tell you.
The research, the body of current literature, and the particular objectives should all influence the structure of a literature review. It is also critical to remember that creating a literature review is an ongoing process - as one reads and analyzes the literature, one's understanding may change, which could require rearranging the literature ...
Chapter 9 Methods for Literature Reviews
Therefore, this paper provides a Systematic Literature Review (SLR) of deep learning-based text summarization in both types (extractive and abstractive) between 2014 and 2023. To the best of our knowledge, this is the first SLR that offers a comprehensive overview of extractive and abstractive text summarization techniques based on Deep ...
View PDF HTML (experimental) Abstract: Recent technological advancements have enhanced our ability to collect and analyze rich multimodal data (e.g., speech, video, and eye gaze) to better inform learning and training experiences. While previous reviews have focused on parts of the multimodal pipeline (e.g., conceptual models and data fusion), a comprehensive literature review on the methods ...
Response: On the basis of all the reviewers' comments, we decided to carry out a systematic analysis of the literature rather than a scoping review, using a second person to screen and review articles in duplicate and by searching other databases. We adapted the objectives to those of a systematic literature review (lines 113-115).