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Writing a Scientific Research Project Proposal

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The importance of a well-written research proposal cannot be underestimated. Your research really is only as good as your proposal. A poorly written, or poorly conceived research proposal will doom even an otherwise worthy project. On the other hand, a well-written, high-quality proposal will increase your chances for success.

In this article, we’ll outline the basics of writing an effective scientific research proposal, including the differences between research proposals, grants and cover letters. We’ll also touch on common mistakes made when submitting research proposals, as well as a simple example or template that you can follow.

What is a scientific research proposal?

The main purpose of a scientific research proposal is to convince your audience that your project is worthwhile, and that you have the expertise and wherewithal to complete it. The elements of an effective research proposal mirror those of the research process itself, which we’ll outline below. Essentially, the research proposal should include enough information for the reader to determine if your proposed study is worth pursuing.

It is not an uncommon misunderstanding to think that a research proposal and a cover letter are the same things. However, they are different. The main difference between a research proposal vs cover letter content is distinct. Whereas the research proposal summarizes the proposal for future research, the cover letter connects you to the research, and how you are the right person to complete the proposed research.

There is also sometimes confusion around a research proposal vs grant application. Whereas a research proposal is a statement of intent, related to answering a research question, a grant application is a specific request for funding to complete the research proposed. Of course, there are elements of overlap between the two documents; it’s the purpose of the document that defines one or the other.

Scientific Research Proposal Format

Although there is no one way to write a scientific research proposal, there are specific guidelines. A lot depends on which journal you’re submitting your research proposal to, so you may need to follow their scientific research proposal template.

In general, however, there are fairly universal sections to every scientific research proposal. These include:

• Title: Make sure the title of your proposal is descriptive and concise. Make it catch and informative at the same time, avoiding dry phrases like, “An investigation…” Your title should pique the interest of the reader.
• Abstract: This is a brief (300-500 words) summary that includes the research question, your rationale for the study, and any applicable hypothesis. You should also include a brief description of your methodology, including procedures, samples, instruments, etc.
• Introduction: The opening paragraph of your research proposal is, perhaps, the most important. Here you want to introduce the research problem in a creative way, and demonstrate your understanding of the need for the research. You want the reader to think that your proposed research is current, important and relevant.
• Background: Include a brief history of the topic and link it to a contemporary context to show its relevance for today. Identify key researchers and institutions also looking at the problem
• Literature Review: This is the section that may take the longest amount of time to assemble. Here you want to synthesize prior research, and place your proposed research into the larger picture of what’s been studied in the past. You want to show your reader that your work is original, and adds to the current knowledge.
• Research Design and Methodology: This section should be very clearly and logically written and organized. You are letting your reader know that you know what you are going to do, and how. The reader should feel confident that you have the skills and knowledge needed to get the project done.
• Preliminary Implications: Here you’ll be outlining how you anticipate your research will extend current knowledge in your field. You might also want to discuss how your findings will impact future research needs.
• Conclusion: This section reinforces the significance and importance of your proposed research, and summarizes the entire proposal.
• References/Citations: Of course, you need to include a full and accurate list of any and all sources you used to write your research proposal.

Common Mistakes in Writing a Scientific Research Project Proposal

Remember, the best research proposal can be rejected if it’s not well written or is ill-conceived. The most common mistakes made include:

• Not providing the proper context for your research question or the problem
• Failing to reference landmark/key studies
• Losing focus of the research question or problem
• Not accurately presenting contributions by other researchers and institutions
• Incompletely developing a persuasive argument for the research that is being proposed
• Misplaced attention on minor points and/or not enough detail on major issues
• Sloppy, low-quality writing without effective logic and flow
• Incorrect or lapses in references and citations, and/or references not in proper format
• The proposal is too long – or too short

Scientific Research Proposal Example

There are countless examples that you can find for successful research proposals. In addition, you can also find examples of unsuccessful research proposals. Search for successful research proposals in your field, and even for your target journal, to get a good idea on what specifically your audience may be looking for.

While there’s no one example that will show you everything you need to know, looking at a few will give you a good idea of what you need to include in your own research proposal. Talk, also, to colleagues in your field, especially if you are a student or a new researcher. We can often learn from the mistakes of others. The more prepared and knowledgeable you are prior to writing your research proposal, the more likely you are to succeed.

One of the top reasons scientific research proposals are rejected is due to poor logic and flow. Check out our Language Editing Services to ensure a great proposal , that’s clear and concise, and properly referenced. Check our video for more information, and get started today.

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Research Proposal Examples for Every Science Field

Looking for research funding can be a daunting task, especially when you are starting out. A great way to improve grant-writing skills is to get inspired by winning research proposal examples.

To assist you in writing a competitive proposal, I have curated a collection of real-life research proposal examples from various scientific disciplines. These examples will allow you to gain inspiration about the way research proposals are structured and written.

Structure of a Research Proposal

A research proposal serves as a road-map for a project, outlining the objectives, methodology, resources, and expected outcomes. The main goal of writing a research proposal is to convince funding agency of the value and feasibility of a research project. But a proposal also helps scientists themselves to clarify their planned approach.

While the exact structure may vary depending on the science field and institutional guidelines, a research proposal typically includes the following sections: Problem, Objectives, Methodology, Resources, Participants, Results&Impact, Dissemination, Timeline, and Budget. I will use this structure for the example research proposals in this article.

Here is a brief description of what each of the nine proposal sections should hold.

A concise and informative title that captures the essence of the research proposal. Sometimes an abstract is required that briefly summarizes the proposed project.

Clearly define the research problem or gap in knowledge that the study aims to address. Present relevant background information and cite existing literature to support the need for further investigation.

State the specific objectives and research questions that the study seeks to answer. These objectives should be clear, measurable, and aligned with the problem statement.

Methodology

Describe the research design, methodology, and techniques that will be employed to collect and analyze data. Justify your chosen approach and discuss its strengths and limitations.

Outline the resources required for the successful execution of the research project, such as equipment, facilities, software, and access to specific datasets or archives.

Participants

Describe the research team’s qualification for implementing the research methodology and their complementary value

Results and Impact

Describe the expected results, outcomes, and potential impact of the research. Discuss how the findings will contribute to the field and address the research gap identified earlier.

Dissemination

Explain how the research results will be disseminated to the academic community and wider audiences. This may include publications, conference presentations, workshops, data sharing or collaborations with industry partners.

Develop a realistic timeline that outlines the major milestones and activities of the research project. Consider potential challenges or delays and incorporate contingency plans.

Provide a detailed budget estimate, including anticipated expenses for research materials, equipment, participant compensation, travel, and other relevant costs. Justify the budget based on the project’s scope and requirements.

Consider that the above-mentioned proposal headings can be called differently depending on the funder’s requirements. However, you can be sure in one proposal’s section or another each of the mentioned sections will be included. Whenever provided, always use the proposal structure as required by the funding agency.

Research Proposal template download

This research proposal template includes the nine headings that we just discussed. For each heading, a key sentence skeleton is provided to help you to kick-start the proposal writing process.

Real-Life Research Proposal Examples

Proposals can vary from field to field so I will provide you with research proposal examples proposals in four main branches of science: social sciences, life sciences, physical sciences, and engineering and technology. For each science field, you will be able to download real-life winning research proposal examples.

To illustrate the principle of writing a scientific proposal while adhering to the nine sections I outlined earlier, for each discipline I will also provide you with a sample hypothetical research proposal. These examples are formulated using the key sentence structure that is included in the download template .

In case the research proposal examples I provide do not hold exactly what you are looking for, use the Open Grants database. It holds approved research proposals from various funding agencies in many countries. When looking for research proposals examples in the database, use the filer to search for specific keywords and organize the results to view proposals that have been funded.

Research Proposals Examples in Social Sciences

Here are real-life research proposal examples of funded projects in social sciences.

Here is an outline of a hypothetical Social Sciences research proposal that is structured using the nine proposal sections we discussed earlier. This proposal example is produced using the key sentence skeleton that you will access in the proposal template .

The Influence of Social Media on Political Participation among Young Adults

Social media platforms have become prominent spaces for political discussions and information sharing. However, the impact of social media on political participation among young adults remains a topic of debate.

With the project, we aim to establish the relationship between social media usage and political engagement among young adults. To achieve this aim, we have three specific objectives:

• Examine the association between social media usage patterns and various forms of political participation, such as voting, attending political rallies, and engaging in political discussions.
• Investigate the role of social media in shaping political attitudes, opinions, and behaviors among young adults.
• Provide evidence-based recommendations for utilizing social media platforms to enhance youth political participation.

During the project, a mixed methods approach, combining quantitative surveys and qualitative interviews will be used to determine the impact of social media use on youth political engagement. In particular, surveys will collect data on social media usage, political participation, and attitudes. Interviews will provide in-depth insights into participants’ experiences and perceptions.

The project will use survey software, transcription tools, and statistical analysis software to statistically evaluate the gathered results. The project will also use project funding for participant compensation.

Principal investigator, Jane Goodrich will lead a multidisciplinary research team comprising social scientists, political scientists, and communication experts with expertise in political science and social media research.

The project will contribute to a better understanding of the influence of social media on political participation among young adults, including:

• inform about the association between social media usage and political participation among youth.
• determine the relationship between social media content and political preferences among youth.
• provide guidelines for enhancing youth engagement in democratic processes through social media use.

We will disseminate the research results within policymakers and NGOs through academic publications in peer-reviewed journals, presentations at relevant conferences, and policy briefs.

The project will start will be completed within two years and for the first two objectives a periodic report will be submitted in months 12 and 18.

The total eligible project costs are 58,800 USD, where 15% covers participant recruitment and compensation, 5% covers survey software licenses, 55% are dedicated for salaries, and 25% are intended for dissemination activities.

Research Proposal Examples in Life Sciences

Here are real-life research project examples in life sciences.

Here is a hypothetical research proposal example in Life Sciences. Just like the previous example, it consists of the nine discussed proposal sections and it is structured using the key sentence skeleton that you will access in the proposal template .

Investigating the Role of Gut Microbiota in Obesity and Metabolic Syndrome (GUT-MET)

Obesity and metabolic syndrome pose significant health challenges worldwide, leading to numerous chronic diseases and increasing healthcare costs. Despite extensive research, the precise mechanisms underlying these conditions remain incompletely understood. A critical knowledge gap exists regarding the role of gut microbiota in the development and progression of obesity and metabolic syndrome.

With the GUT-MET project, we aim to unravel the complex interactions between gut microbiota and obesity/metabolic syndrome. To achieve this aim, we have the following specific objectives:

• Investigate the composition and diversity of gut microbiota in individuals with obesity and metabolic syndrome.
• Determine the functional role of specific gut microbial species and their metabolites in the pathogenesis of obesity and metabolic syndrome.

During the project, we will employ the following key methodologies:

• Perform comprehensive metagenomic and metabolomic analyses to characterize the gut microbiota and associated metabolic pathways.
• Conduct animal studies to investigate the causal relationship between gut microbiota alterations and the development of obesity and metabolic syndrome.

The project will benefit from state-of-the-art laboratory facilities, including advanced sequencing and analytical equipment, as well as access to a well-established cohort of participants with obesity and metabolic syndrome.

Dr. Emma Johnson, a renowned expert in gut microbiota research and Professor of Molecular Biology at the University of PeerRecognized, will lead the project. Dr. Johnson has published extensively in high-impact journals and has received multiple research grants focused on the gut microbiota and metabolic health.

The project will deliver crucial insights into the role of gut microbiota in obesity and metabolic syndrome. Specifically, it will:

• Identify microbial signatures associated with obesity and metabolic syndrome for potential diagnostic and therapeutic applications.
• Uncover key microbial metabolites and pathways implicated in disease development, enabling the development of targeted interventions.

We will actively disseminate the project results within the scientific community, healthcare professionals, and relevant stakeholders through publications in peer-reviewed journals, presentations at international conferences, and engagement with patient advocacy groups.

The project will be executed over a period of 36 months. Key milestones include data collection and analysis, animal studies, manuscript preparation, and knowledge transfer activities.

The total eligible project costs are $1,500,000, with the budget allocated for 55% personnel, 25% laboratory supplies, 5% data analysis, and 15% knowledge dissemination activities as specified in the research call guidelines.

Research Proposals Examples in Natural Sciences

Here are real-life research proposal examples of funded projects in natural sciences.

Here is a Natural Sciences research proposal example that is structured using the same nine sections. I created this proposal example using the key sentence skeleton that you will access in the proposal template .

Assessing the Impact of Climate Change on Biodiversity Dynamics in Fragile Ecosystems (CLIM-BIODIV)

Climate change poses a significant threat to global biodiversity, particularly in fragile ecosystems such as tropical rainforests and coral reefs. Understanding the specific impacts of climate change on biodiversity dynamics within these ecosystems is crucial for effective conservation and management strategies. However, there is a knowledge gap regarding the precise mechanisms through which climate change influences species composition, population dynamics, and ecosystem functioning in these vulnerable habitats.

With the CLIM-BIODIV project, we aim to assess the impact of climate change on biodiversity dynamics in fragile ecosystems. To achieve this aim, we have the following specific objectives:

• Investigate how changes in temperature and precipitation patterns influence species distributions and community composition in tropical rainforests.
• Assess the effects of ocean warming and acidification on coral reef ecosystems, including changes in coral bleaching events, species diversity, and ecosystem resilience.
• Conduct field surveys and employ remote sensing techniques to assess changes in species distributions and community composition in tropical rainforests.
• Utilize experimental approaches and long-term monitoring data to evaluate the response of coral reefs to varying temperature and pH conditions.

The project will benefit from access to field sites in ecologically sensitive regions, advanced remote sensing technology, and collaboration with local conservation organizations to facilitate data collection and knowledge sharing.

Dr. Alexander Chen, an established researcher in climate change and biodiversity conservation, will lead the project. Dr. Chen is a Professor of Ecology at the University of Peer Recognized, with a track record of three Nature publications and successful grant applications exceeding 25 million dollars.

The project will provide valuable insights into the impacts of climate change on biodiversity dynamics in fragile ecosystems. It will:

• Enhance our understanding of how tropical rainforest communities respond to climate change, informing targeted conservation strategies.
• Contribute to the identification of vulnerable coral reef ecosystems and guide management practices for their protection and resilience.

We will disseminate the project results to the scientific community, conservation practitioners, and policymakers through publications in reputable journals, participation in international conferences, and engagement with local communities and relevant stakeholders.

The project will commence on March 1, 2024, and will be implemented over a period of 48 months. Key milestones include data collection and analysis, modeling exercises, stakeholder engagement, and knowledge transfer activities. These are summarized in the Gantt chart.

The total eligible project costs are $2,000,000, with budget allocation for research personnel, fieldwork expenses, laboratory analyses, modeling software, data management, and dissemination activities.

Research Proposal Examples in Engineering and Technology

Here are real-life research proposal examples of funded research projects in the field of science and technology.

Here is a hypothetical Engineering and Technology research proposal example that is structured using the same nine proposal sections we discussed earlier. I used the key sentence skeleton available in the proposal template to produce this example.

Developing Sustainable Materials for Energy-Efficient Buildings (SUST-BUILD)

The construction industry is a major contributor to global energy consumption and greenhouse gas emissions. Addressing this issue requires the development of sustainable materials that promote energy efficiency in buildings. However, there is a need for innovative engineering solutions to overcome existing challenges related to the performance, cost-effectiveness, and scalability of such materials.

With the SUST-BUILD project, we aim to develop sustainable materials for energy-efficient buildings. Our specific objectives are as follows:

• Design and optimize novel insulating materials with enhanced thermal properties and reduced environmental impact.
• Develop advanced coatings and surface treatments to improve the energy efficiency and durability of building envelopes.
• Conduct extensive material characterization and simulation studies to guide the design and optimization of insulating materials.
• Utilize advanced coating techniques and perform full-scale testing to evaluate the performance and durability of building envelope treatments.

The project will benefit from access to state-of-the-art laboratory facilities, including material testing equipment, thermal analysis tools, and coating application setups. Collaboration with industry partners will facilitate the translation of research findings into practical applications.

Dr. Maria Rodriguez, an experienced researcher in sustainable materials and building technologies, will lead the project. Dr. Rodriguez holds a position as Associate Professor in the Department of Engineering at Peer Recognized University and has a strong publication record and expertise in the field.

The project will deliver tangible outcomes for energy-efficient buildings. It will:

• Develop sustainable insulating materials with superior thermal performance, contributing to reduced energy consumption and greenhouse gas emissions in buildings.
• Introduce advanced coatings and surface treatments developed from sustainable materials that enhance the durability and energy efficiency of building envelopes, thereby improving long-term building performance.

We will disseminate project results to relevant stakeholders, including industry professionals, architects, and policymakers. This will be accomplished through publications in scientific journals, presentations at conferences and seminars, and engagement with industry associations.

The project will commence on September 1, 2024, and will be implemented over a period of 36 months. Key milestones include material development and optimization, performance testing, prototype fabrication, and knowledge transfer activities. The milestones are summarized in the Gantt chart.

The total eligible project costs are $1,800,000. The budget will cover personnel salaries (60%), materials and equipment (10%), laboratory testing (5%), prototyping (15%), data analysis (5%), and dissemination activities (5%) as specified in the research call guidelines.

Final Tips for Writing an Winning Research Proposal

Come up with a good research idea.

Ideas are the currency of research world. I have prepared a 3 step approach that will help you to come up with a research idea that is worth turning into a proposal. You can download the Research Idea Generation Toolkit in this article.

Start with a strong research outline

Before even writing one sentence of the research proposal, I suggest you use the Research Project Canvas . It will help you to first come up with different research ideas and then choose the best one for writing a full research proposal.

Tailor to the requirements of the project funder

Treat the submission guide like a Monk treats the Bible and follow its strict requirements to the last detail. The funder might set requirements for the topic, your experience, employment conditions, host institution, the research team, funding amount, and so forth. 

What you would like to do in the research is irrelevant unless it falls within the boundaries defined by the funder.

Make the reviewer’s job of finding flaws in your proposal difficult by ensuring that you have addressed each requirement clearly. If applicable, you can even use a table with requirements versus your approach. This will make your proposed approach absolutely evident for the reviewers.

Before submitting, assess your proposal using the criteria reviewers have to follow.

Conduct thorough background research

Before writing your research proposal, conduct comprehensive background research to familiarize yourself with existing literature, theories, and methodologies related to your topic. This will help you identify research gaps and formulate research questions that address these gaps. You will also establish competence in the eyes of reviewers by citing relevant literature.

Be concise and clear

Define research questions that are specific, measurable, and aligned with the problem statement.

If you think the reviewers might be from a field outside your own, avoid unnecessary jargon or complex language to help them to understand the proposal better.

Be specific in describing the research methodology. For example, include a brief description of the experimental methods you will rely upon, add a summary of the materials that you are going to use, attach samples of questionnaires that you will use, and include any other proof that demonstrates the thoroughness you have put into developing the research plan. Adding a flowchart is a great way to present the methodology.

Create a realistic timeline and budget

Develop a realistic project timeline that includes key milestones and activities, allowing for potential challenges or delays. Similarly, create a detailed budget estimate that covers all anticipated expenses, ensuring that it aligns with the scope and requirements of your research project. Be transparent and justify your budget allocations.

Demonstrate the significance and potential impact of the research

Clearly articulate the significance of your research and its potential impact on the field. Discuss how your findings can contribute to theory development, practical applications, policy-making, or other relevant areas.

Pay attention to formatting and style guidelines

Follow the formatting and style guidelines provided by your institution or funding agency. Pay attention to details such as font size, margins, referencing style, and section headings. Adhering to these guidelines demonstrates professionalism and attention to detail.

Take a break before editing

After preparing the first draft, set it aside for at least a week. Then thoroughly check it for logic and revise, revise, revise. Use the proposal submission guide to review your proposal against the requirements. Remember to use grammar checking tools to check for errors.

Finally, read the proposal out loud. This will help to ensure good readability.

Seek feedback

Share your proposal with mentors, colleagues, or members of your research community to receive constructive feedback and suggestions for improvement. Take these seriously since they provide a third party view of what is written (instead of what you think you have written).

Reviewing good examples is one of the best ways to learn a new skill. I hope that the research proposal examples in this article will be useful for you to get going with writing your own research proposal.

Have fun with the writing process and I hope your project gets approved!

Learning from research proposal examples alone is not enough

The research proposal examples I provided will help you to improve your grant writing skills. But learning from example proposals alone will take you a rather long time to master writing winning proposals.

To write a winning research proposal, you have to know how to add that elusive X-Factor that convinces the reviewers to move your proposal from the category “good” to the category “support”. This includes creating self-explanatory figures, creating a budget, collaborating with co-authors, and presenting a convincing story.

To write a research proposal that maximizes your chances of receiving research funding, read my book “ Write a Winning Research Proposal “.

This isn’t just a book. It’s a complete research proposal writing toolkit that includes a  project ideation canvas, budget spreadsheet, project rating scorecard, virtual collaboration whiteboard, proposal pitch formula, graphics creation cheat sheet, review checklist and other valuable resources that will help you succeed.

Hey! My name is Martins Zaumanis and I am a materials scientist in Switzerland ( Google Scholar ). As the first person in my family with a PhD, I have first-hand experience of the challenges starting scientists face in academia. With this blog, I want to help young researchers succeed in academia. I call the blog “Peer Recognized”, because peer recognition is what lifts academic careers and pushes science forward.

Besides this blog, I have written the Peer Recognized book series and created the Peer Recognized Academy offering interactive online courses.

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Hi Martins, I’ve recently discovered your content and it is great. I will be implementing much of it into my workflow, as well as using it to teach some graduate courses! I noticed that a materials science-focused proposal could be a very helpful addition.

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8 Structure of a Scientific Research Proposal

In Biocore lab you will write research proposal papers before you collect data for your research projects. A research proposal is a very important first step that helps you get familiar with your system and serves as a guide for your entire project. The proposal has many similar attributes as a lab paper (discussed in the previous section) and shares nearly all the same components; Introduction, Materials and Methods, and Expected & Alternative Results. We call the final section “Implications” rather than a “Discussion ” to emphasize the potential impact of the predicted expected and alternative results.

Below we point out how proposals differ from final lab papers and provide guidelines for what should be included in this type of paper. When writing about what you propose to do, use the future tense . No abstract is necessary for research proposals.

Make sure to review the Research Proposal Rubric as you are writing!!

See Final Lab Report Title section description and examples. How does a proposal title compare to a title for a final paper? Compare rubrics.

Introduction

Include a summary of background information, experimental question, biological rationale, hypothesis, and experimental approach. As you become more familiar with your system during your study, you will likely need to revise this section for your final paper to reflect the greater depth of your knowledge or unanticipated variables that become clear as the study progresses.

The methods section is usually quite detailed and may include diagrams or flow charts explaining your experimental design and protocols. Include a description of any pilot studies you plan to do.

Expected and Alternative Results

Since you have not done the experiment yet, you will not have any data. However, your hypothesis is a clear statement of what you expect and should provide the basis for this section. Provide a graph of the data you expect if your hypothesis is supported, showing actual numbers on labeled axes. This data is ‘dummy data’ – you make it up to represent expected trends and variation based on your current knowledge of the system. It could be based on your own pilot studies and/or published data from similar studies. Text accompanying this section should point out expected trends and describe pertinent attributes of trend lines. You should also present biologically plausible alternative results to those you expect , e.g ., opposite results or the “no difference” result. (Do not present alternative results that represent flawed mechanical assumptions.) Thinking about alternative results at the proposal stage may help you troubleshoot problems, evaluate the efficacy of your control, or provide a background for your final results since, quite often, these are the ones you actually see at the end of your experiment.

Implications & Conclusions

In this section, describe the implications of the predicted trend described in your expected results as it relates to the knowledge gap and the broader rationale presented in your Introduction. Remind the reader of the biological and methodological assumptions you are making, and limitations of your experiment. Discuss your alternative results and explain how they might yield from incomplete or alternative rationale or unanticipated variables. Describe limiting factors ( e.g . replication, controls etc.), and evaluate your confidence in the experimental design and/or your capacity to make broad conclusions. Finish off with a strong conclusion, with a description of ramifications if your hypothesis is supported. Special note on avoiding social justifications: You should not over emphasize the relevance of your experiment and the possible connections to large-scale processes. Be realistic and logical —do not over generalize or state grand implications that are not sensible given the structure of your experimental system. Not all science is easily applied to improving the human condition (cure cancer or solve climate change). Performing an investigation just for the sake of adding to our scientific knowledge (“basic science”) is important too. In fact, basic science often provides the foundation for applied studies.

Example of Good Implications

Adapted from a paper by Claire Evensen- Biocore 382 Fall 2017

Inoculation of Solidago canadensis with rust fungus expected to result in higher infection severity on younger, upper leaves as compared to older, lower leaves

Knowledge Gap: Although it is known that rust fungus infects S. canadensis leaf tissue (Novander and Smith 1995), it is not known if infection severity is influenced by leaf age, nor is it know if the age gradient across a single plant from older leaves on the lower stem to younger leaves on the upper stem is significant enough to result in differences in infection severity.

Implications:

If we see differences in infection severity between older and younger leaves treated with a fungal spray, the study will support the idea that stomatal opening arising from differences in leaf age is an important factor in rust fungus infection. Though it was previously know that infections occur via the stomata, it was unclear whether the variation in stomatal opening associated with leaf age was distinct enough to either hinder or advance the fungal infection process. Although we are not measuring the degree of stomatal opening or closure, if we support our hypothesis that younger leaves are more susceptible to infection than older leaves, our data would suggest that the age of leaf including lack of open stomata more prevalent in older leaves dramatically lowers the probability of the fungal germ tube finding an insertion site—to the point that a large proportion of spores that adhere to the leaves are unsuccessful in entering the host tissue (Bradley et al. 2007). An alternative explanation for higher infection rate on younger leaves is simply associated with stem height, with fungal spores more easily spread by wind to leaves that are higher on the plant stem as opposed to older leaves that are less exposed and lower on the stem (Novander and Smith 1995). Regardless of the mechanism, our work will provide valuable insight into how the relationship between the rust fungus and S. canadensis changes with leaf age. (Referring back to biorationale and comparing expected results with knowledge gap).

If our study yields alternative results and we reject our hypothesis, we could conclude that either our assumptions regarding stomata opening and age are flawed or there are unanticipated confounding factors influencing our study.  We assume that older leaves would have fewer stomata openings and would, therefore, provide fewer opportunities for fungal infections in the older leaf tissue. However, if the rust fungus germ tube is highly efficient in terms of leaf coverage, or if a robust infection only requires a baseline threshold of a “few” stomata, and if there are enough stomata available to be sufficient for infection even when a leaf has almost completely senesced, we will likely not see statistically significant differences in infection between younger and older leaves. An important additional variable includes the presence of prior infections. In other words, we may spray plants that were already infected with spores that had yet to germinate. Should this occur, statistically significant differences in infection rate? may be masked by a previous rust infection. (Explaining how assumptions, unanticipated variables, and limiting factors, here and below, could yield alternative results)

Our study is limited by our inability to control the presence of naturally occurring wind-borne rust spores. We assume that a single wind-borne spore has a low probability of adhering to a S. canadensis leaf, however it is possible for natural infection to contaminate and obscure potential differences due to our inoculation treatments. This experiment will be done in a field setting in the Biocore Prairie. As such, we have located a patch of S. canadensis with no apparent infection that is isolated from infected patches of other S. canadensis plants. We will be creating a spray inoculant at saturating concentration and at a much higher concentration than naturally occurring spores could achieve. Both the treated and control plants will be isolated by dense vegetation and therefore, will be much more likely targets of infection by our treatments than by natural infection. If there is any contamination by naturally occurring wind-borne spores, we will detect it on our control group’s extent of infection following the experiment. The extent of infection by non-inoculated control plants will serve as a baseline for comparison to the two treatment groups. ( Reminding the reader of the biological and methodological assumptions you are making, and limitations of your experiment.)

Finally, we assume that the Tween-20 solution will be a suitable temporary environment for spores. Rust fungus is highly dependent on its relationship with its host plant (Petersen 1974), so it may be weakened or die when it is removed from the host. Should this occur, we will expect to see low levels of infection across all three groups, as manual infection attempts would fail. Nevertheless, we are confident in our design given the timing of our study in mid-Sept when the life cycles of both the host and the fungus align; the ideal germination temperature for the fungus of 37°C will be achieved; and that previous studies have found success with the 0.01% Tween-20 solution (Stavely 1983). (Evaluation of confidence in method)

In conclusion, we believe our rationale regarding stomatal infection mechanism, and the relationship of stomatal opening and leaf age is sound. Although there is literature describing the mechanism of rust fungal infection through stomatal opening, to our understanding, it is not established that infection by the S. canadensis leaf rust fungus is associated with leaf age. If our hypothesis regarding leaf age of S. canadensis and rust infection severity is supported, we can better predict incidence and timing of rust infection on S. canadensis and can furthermore, support questions about control and spread of S. canadensis and this fungal leaf pathogen. (Ramifications if hypothesis is supported)

Process of Science Companion: Science Communication Copyright © 2017 by University of Wisconsin-Madison Biology Core Curriculum (Biocore) is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License , except where otherwise noted.

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Writing a Theoretical Research Proposal Bioscene 17 Engaging Biology Undergraduates in the Scientific Process Through Writing a Theoretical Research Proposal

Abstract: It has been suggested that research experiences are an important element that should be included in all undergraduate Biology curricula. This is a difficult suggestion to accommodate due to issues with cost, space and time. We addressed this challenge through development of a capstone project in which Biology majors work in groups to develop novel theoretical research proposals with guidance from a faculty mentor. Though students are not directly working at the bench, they are being mentored in aspects of the scientific process such as synthesizing information from the literature, asking novel research questions, constructing logical aims, designing experiments and writing scientifically. Since this project began, we have mentored 417 students in proposal writing and have assessed their experiences through pre- and post-surveys. Students have made gains in several areas, but most notably in their ability to pose novel questions and develop an experimental plan, and in the ...

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• Biological Procedures Online Biological Procedures Online, from BioMed Central, publishes articles that improve access to techniques and methods in the medical and biological sciences.
• Introduction to Designing Experiments A 7-part series from Films on Demand that includes how to design research, hypotheses, sampling, ethics and bias, and more.
• Exploring Qualitative Methods How to conduct research using qualitative data from Films on Demand.
• Organizing Quantitative Data Video from Films on Demand on using quantitative data.
• Statistics for Biologists This resource from Nature magazine offers guidance in using statistics in biology research

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How to prepare a Research Proposal

Health research, medical education and clinical practice form the three pillars of modern day medical practice. As one authority rightly put it: ‘Health research is not a luxury, but an essential need that no nation can afford to ignore’. Health research can and should be pursued by a broad range of people. Even if they do not conduct research themselves, they need to grasp the principles of the scientific method to understand the value and limitations of science and to be able to assess and evaluate results of research before applying them. This review paper aims to highlight the essential concepts to the students and beginning researchers and sensitize and motivate the readers to access the vast literature available on research methodologies.

Most students and beginning researchers do not fully understand what a research proposal means, nor do they understand its importance. 1 A research proposal is a detailed description of a proposed study designed to investigate a given problem. 2

A research proposal is intended to convince others that you have a worthwhile research project and that you have the competence and the work-plan to complete it. Broadly the research proposal must address the following questions regardless of your research area and the methodology you choose: What you plan to accomplish, why do you want to do it and how are you going to do it. 1 The aim of this article is to highlight the essential concepts and not to provide extensive details about this topic.

The elements of a research proposal are highlighted below:

1. Title: It should be concise and descriptive. It must be informative and catchy. An effective title not only prick’s the readers interest, but also predisposes him/her favorably towards the proposal. Often titles are stated in terms of a functional relationship, because such titles clearly indicate the independent and dependent variables. 1 The title may need to be revised after completion of writing of the protocol to reflect more closely the sense of the study. 3

2. Abstract: It is a brief summary of approximately 300 words. It should include the main research question, the rationale for the study, the hypothesis (if any) and the method. Descriptions of the method may include the design, procedures, the sample and any instruments that will be used. 1 It should stand on its own, and not refer the reader to points in the project description. 3

3. Introduction: The introduction provides the readers with the background information. Its purpose is to establish a framework for the research, so that readers can understand how it relates to other research. 4 It should answer the question of why the research needs to be done and what will be its relevance. It puts the proposal in context. 3

The introduction typically begins with a statement of the research problem in precise and clear terms. 1

The importance of the statement of the research problem 5 : The statement of the problem is the essential basis for the construction of a research proposal (research objectives, hypotheses, methodology, work plan and budget etc). It is an integral part of selecting a research topic. It will guide and put into sharper focus the research design being considered for solving the problem. It allows the investigator to describe the problem systematically, to reflect on its importance, its priority in the country and region and to point out why the proposed research on the problem should be undertaken. It also facilitates peer review of the research proposal by the funding agencies.

Then it is necessary to provide the context and set the stage for the research question in such a way as to show its necessity and importance. 1 This step is necessary for the investigators to familiarize themselves with existing knowledge about the research problem and to find out whether or not others have investigated the same or similar problems. This step is accomplished by a thorough and critical review of the literature and by personal communication with experts. 5 It helps further understanding of the problem proposed for research and may lead to refining the statement of the problem, to identify the study variables and conceptualize their relationships, and in formulation and selection of a research hypothesis. 5 It ensures that you are not "re-inventing the wheel" and demonstrates your understanding of the research problem. It gives due credit to those who have laid the groundwork for your proposed research. 1 In a proposal, the literature review is generally brief and to the point. The literature selected should be pertinent and relevant. 6

Against this background, you then present the rationale of the proposed study and clearly indicate why it is worth doing.

4. Objectives: Research objectives are the goals to be achieved by conducting the research. 5 They may be stated as ‘general’ and ‘specific’.

The general objective of the research is what is to be accomplished by the research project, for example, to determine whether or not a new vaccine should be incorporated in a public health program.

The specific objectives relate to the specific research questions the investigator wants to answer through the proposed study and may be presented as primary and secondary objectives, for example, primary: To determine the degree of protection that is attributable to the new vaccine in a study population by comparing the vaccinated and unvaccinated groups. 5 Secondary: To study the cost-effectiveness of this programme.

Young investigators are advised to resist the temptation to put too many objectives or over-ambitious objectives that cannot be adequately achieved by the implementation of the protocol. 3

5. Variables: During the planning stage, it is necessary to identify the key variables of the study and their method of measurement and unit of measurement must be clearly indicated. Four types of variables are important in research 5 :

a. Independent variables: variables that are manipulated or treated in a study in order to see what effect differences in them will have on those variables proposed as being dependent on them. The different synonyms for the term ‘independent variable’ which are used in literature are: cause, input, predisposing factor, risk factor, determinant, antecedent, characteristic and attribute.

b. Dependent variables: variables in which changes are results of the level or amount of the independent variable or variables.

Synonyms: effect, outcome, consequence, result, condition, disease.

c. Confounding or intervening variables: variables that should be studied because they may influence or ‘mix’ the effect of the independent variables. For instance, in a study of the effect of measles (independent variable) on child mortality (dependent variable), the nutritional status of the child may play an intervening (confounding) role.

d. Background variables: variables that are so often of relevance in investigations of groups or populations that they should be considered for possible inclusion in the study. For example sex, age, ethnic origin, education, marital status, social status etc.

The objective of research is usually to determine the effect of changes in one or more independent variables on one or more dependent variables. For example, a study may ask "Will alcohol intake (independent variable) have an effect on development of gastric ulcer (dependent variable)?"

Certain variables may not be easy to identify. The characteristics that define these variables must be clearly identified for the purpose of the study.

6. Questions and/ or hypotheses: If you as a researcher know enough to make prediction concerning what you are studying, then the hypothesis may be formulated. A hypothesis can be defined as a tentative prediction or explanation of the relationship between two or more variables. In other words, the hypothesis translates the problem statement into a precise, unambiguous prediction of expected outcomes. Hypotheses are not meant to be haphazard guesses, but should reflect the depth of knowledge, imagination and experience of the investigator. 5 In the process of formulating the hypotheses, all variables relevant to the study must be identified. For example: "Health education involving active participation by mothers will produce more positive changes in child feeding than health education based on lectures". Here the independent variable is types of health education and the dependent variable is changes in child feeding.

A research question poses a relationship between two or more variables but phrases the relationship as a question; a hypothesis represents a declarative statement of the relations between two or more variables. 7

For exploratory or phenomenological research, you may not have any hypothesis (please do not confuse the hypothesis with the statistical null hypothesis). 1 Questions are relevant to normative or census type research (How many of them are there? Is there a relationship between them?). Deciding whether to use questions or hypotheses depends on factors such as the purpose of the study, the nature of the design and methodology, and the audience of the research (at times even the outlook and preference of the committee members, particularly the Chair). 6

7. Methodology: The method section is very important because it tells your research Committee how you plan to tackle your research problem. The guiding principle for writing the Methods section is that it should contain sufficient information for the reader to determine whether the methodology is sound. Some even argue that a good proposal should contain sufficient details for another qualified researcher to implement the study. 1 Indicate the methodological steps you will take to answer every question or to test every hypothesis illustrated in the Questions/hypotheses section. 6 It is vital that you consult a biostatistician during the planning stage of your study, 8 to resolve the methodological issues before submitting the proposal.

This section should include:

Research design: The selection of the research strategy is the core of research design and is probably the single most important decision the investigator has to make. The choice of the strategy, whether descriptive, analytical, experimental, operational or a combination of these depend on a number of considerations, 5 but this choice must be explained in relation to the study objectives. 3

Research subjects or participants: Depending on the type of your study, the following questions should be answered 3 , 5

• - What are the criteria for inclusion or selection?
• - What are the criteria for exclusion?
• - What is the sampling procedure you will use so as to ensure representativeness and reliability of the sample and to minimize sampling errors? The key reason for being concerned with sampling is the issue of validity-both internal and external of the study results. 9
• - Will there be use of controls in your study? Controls or comparison groups are used in scientific research in order to increase the validity of the conclusions. Control groups are necessary in all analytical epidemiological studies, in experimental studies of drug trials, in research on effects of intervention programmes and disease control measures and in many other investigations. Some descriptive studies (studies of existing data, surveys) may not require control groups.
• - What are the criteria for discontinuation?

Sample size: The proposal should provide information and justification (basis on which the sample size is calculated) about sample size in the methodology section. 3 A larger sample size than needed to test the research hypothesis increases the cost and duration of the study and will be unethical if it exposes human subjects to any potential unnecessary risk without additional benefit. A smaller sample size than needed can also be unethical as it exposes human subjects to risk with no benefit to scientific knowledge. Calculation of sample size has been made easy by computer software programmes, but the principles underlying the estimation should be well understood.

Interventions: If an intervention is introduced, a description must be given of the drugs or devices (proprietary names, manufacturer, chemical composition, dose, frequency of administration) if they are already commercially available. If they are in phases of experimentation or are already commercially available but used for other indications, information must be provided on available pre-clinical investigations in animals and/or results of studies already conducted in humans (in such cases, approval of the drug regulatory agency in the country is needed before the study). 3

Ethical issues 3 : Ethical considerations apply to all types of health research. Before the proposal is submitted to the Ethics Committee for approval, two important documents mentioned below (where appropriate) must be appended to the proposal. In additions, there is another vital issue of Conflict of Interest, wherein the researchers should furnish a statement regarding the same.

The Informed consent form (informed decision-making): A consent form, where appropriate, must be developed and attached to the proposal. It should be written in the prospective subjects’ mother tongue and in simple language which can be easily understood by the subject. The use of medical terminology should be avoided as far as possible. Special care is needed when subjects are illiterate. It should explain why the study is being done and why the subject has been asked to participate. It should describe, in sequence, what will happen in the course of the study, giving enough detail for the subject to gain a clear idea of what to expect. It should clarify whether or not the study procedures offer any benefits to the subject or to others, and explain the nature, likelihood and treatment of anticipated discomfort or adverse effects, including psychological and social risks, if any. Where relevant, a comparison with risks posed by standard drugs or treatment must be included. If the risks are unknown or a comparative risk cannot be given it should be so stated. It should indicate that the subject has the right to withdraw from the study at any time without, in any way, affecting his/her further medical care. It should assure the participant of confidentiality of the findings.

Ethics checklist: The proposal must describe the measures that will be undertaken to ensure that the proposed research is carried out in accordance with the World Medical Association Declaration of Helsinki on Ethical Principles for Medical research involving Human Subjects. 10 It must answer the following questions:

• • Is the research design adequate to provide answers to the research question? It is unethical to expose subjects to research that will have no value.
• • Is the method of selection of research subjects justified? The use of vulnerable subjects as research participants needs special justification. Vulnerable subjects include those in prison, minors and persons with mental disability. In international research it is important to mention that the population in which the study is conducted will benefit from any potential outcome of the research and the research is not being conducted solely for the benefit of some other population. Justification is needed for any inducement, financial or otherwise, for the participants to be enrolled in the study.
• • Are the interventions justified, in terms of risk/benefit ratio? Risks are not limited to physical harm. Psychological and social risks must also be considered.
• • For observations made, have measures been taken to ensure confidentiality?

Research setting 5 : The research setting includes all the pertinent facets of the study, such as the population to be studied (sampling frame), the place and time of study.

Study instruments 3 , 5 : Instruments are the tools by which the data are collected. For validated questionnaires/interview schedules, reference to published work should be given and the instrument appended to the proposal. For new a questionnaire which is being designed specifically for your study the details about preparing, precoding and pretesting of questionnaire should be furnished and the document appended to the proposal. Descriptions of other methods of observations like medical examination, laboratory tests and screening procedures is necessary- for established procedures, reference of published work cited but for new or modified procedure, an adequate description is necessary with justification for the same.

Collection of data: A short description of the protocol of data collection. For example, in a study on blood pressure measurement: time of participant arrival, rest for 5p. 10 minutes, which apparatus (standard calibrated) to be used, in which room to take measurement, measurement in sitting or lying down position, how many measurements, measurement in which arm first (whether this is going to be randomized), details of cuff and its placement, who will take the measurement. This minimizes the possibility of confusion, delays and errors.

Data analysis: The description should include the design of the analysis form, plans for processing and coding the data and the choice of the statistical method to be applied to each data. What will be the procedures for accounting for missing, unused or spurious data?

Monitoring, supervision and quality control: Detailed statement about the all logistical issues to satisfy the requirements of Good Clinical Practices (GCP), protocol procedures, responsibilities of each member of the research team, training of study investigators, steps taken to assure quality control (laboratory procedures, equipment calibration etc)

Gantt chart: A Gantt chart is an overview of tasks/proposed activities and a time frame for the same. You put weeks, days or months at one side, and the tasks at the other. You draw fat lines to indicate the period the task will be performed to give a timeline for your research study (take help of tutorial on youtube). 11

Significance of the study: Indicate how your research will refine, revise or extend existing knowledge in the area under investigation. How will it benefit the concerned stakeholders? What could be the larger implications of your research study?

Dissemination of the study results: How do you propose to share the findings of your study with professional peers, practitioners, participants and the funding agency?

Budget: A proposal budget with item wise/activity wise breakdown and justification for the same. Indicate how will the study be financed.

References: The proposal should end with relevant references on the subject. For web based search include the date of access for the cited website, for example: add the sentence "accessed on June 10, 2008".

Appendixes: Include the appropriate appendixes in the proposal. For example: Interview protocols, sample of informed consent forms, cover letters sent to appropriate stakeholders, official letters for permission to conduct research. Regarding original scales or questionnaires, if the instrument is copyrighted then permission in writing to reproduce the instrument from the copyright holder or proof of purchase of the instrument must be submitted.

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Research in the Biological and Life Sciences: A Guide for Cornell Researchers: Literature Reviews

• Books and Dissertations
• Databases and Journals
• Locating Theses
• Resource Not at Cornell?
• Citing Sources
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• Measuring your research impact
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What is a Literature Review?

A literature review is a body of text that aims to review the critical points of current knowledge on a particular topic. Most often associated with science-oriented literature, such as a thesis, the literature review usually proceeds a research proposal, methodology and results section. Its ultimate goals is to bring the reader up to date with current literature on a topic and forms that basis for another goal, such as the justification for future research in the area. (retrieved from  http://en.wikipedia.org/wiki/Literature_review )

Writing a Literature Review

The literature review is the section of your paper in which you cite and briefly review the related research studies that have been conducted. In this space, you will describe the foundation on which  your  research will be/is built. You will:

• discuss the work of others
• evaluate their methods and findings
• identify any gaps in their research
• state how  your  research is different

The literature review should be selective and should group the cited studies in some logical fashion.

If you need some additional assistance writing your literature review, the Knight Institute for Writing in the Disciplines offers a  Graduate Writing Service .

Demystifying the Literature Review

For more information, visit our guide devoted to " Demystifying the Literature Review " which includes:

• guide to conducting a literature review,
• a recorded 1.5 hour workshop covering the steps of a literature review, a checklist for drafting your topic and search terms, citation management software for organizing your results, and database searching.

Online Resources

• A Guide to Library Research at Cornell University
• Literature Reviews: An Overview for Graduate Students North Carolina State University 
• The Literature Review: A Few Tips on Conducting Written by Dena Taylor, Director, Health Sciences Writing Centre, and Margaret Procter, Coordinator, Writing Support, University of Toronto
• How to Write a Literature Review University Library, University of California, Santa Cruz
• Review of Literature The Writing Center, University of Wisconsin-Madison

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Science & Quantitative Reasoning Education

Yale undergraduate research, how to write a proposal.

The abstract should summarize your proposal. Include one sentence to introduce the problem you are investigating, why this problem is significant, the hypothesis to be tested, a brief summary of experiments that you wish to conduct and a single concluding sentence. (250 word limit)

Introduction

The introduction discusses the background and significance of the problem you are investigating. Lead the reader from the general to the specific. For example, if you want to write about the role that Brca1 mutations play in breast cancer pathogenesis, talk first about the significance of breast cancer as a disease in the US/world population, then about familial breast cancer as a small subset of breast cancers in general, then about discovery of Brca1 mutations in familial breast cancer, then Brca1’s normal functions in DNA repair, then about how Brca1 mutations result in damaged DNA and onset of familial breast cancer, etc. Definitely include figures with properly labeled text boxes (designated as Figure 1, Figure 2, etc) here to better illustrate your points and help your reader wade through unfamiliar science. (3 pages max)

Formulate a hypothesis that will be tested in your grant proposal. Remember, you are doing hypothesis-driven research so there should be a hypothesis to be tested! The hypothesis should be focused, concise and flow logically from the introduction. For example, your hypothesis could be “I hypothesize that overexpressing wild type Brca1 in Brca1 null tumor cells will prevent metastatic spread in a mouse xenograph model.” Based on your hypothesis, your Specific Aims section should be geared to support it. The hypothesis is stated in one sentence in the proposal. 

Specific Aims (listed as Specific Aim 1, Specific Aim 2)

This is where you will want to work with your mentor to craft the experimental portion of your proposal. Propose two original specific aims to test your hypothesis. Don’t propose more than two aims-you will NOT have enough time to do more. In the example presented, Specific Aim 1 might be “To determine the oncogenic potential of Brca1 null cell lines expressing wild type Brca1 cDNA”. Specific aim 2 might be “To determine the metastatic potential of Brca1 null cells that express WT Brca1”. You do not have to go into extensive technical details, just enough for the reader to understand what you propose to do. The best aims yield mechanistic insights-that is, experiments proposed address some mechanisms of biology. A less desirable aim proposes correlative experiments that does not address mechanistically how BRCA1 mutations generate cancer. It is also very important that the two aims are related but NOT interdependent. What this means is that if Aim 1 doesn’t work, Aim 2 is not automatically dead. For example, say you propose in Aim 1 to generate a BRCA1 knockout mouse model, and in Aim 2 you will take tissues from this mouse to do experiments. If knocking out BRCA1 results in early embryonic death, you will never get a mouse that yields tissues for Aim 2. You can include some of your mentor’s data here as “Preliminary data”. Remember to carefully cite all your sources. (4 pages max; 2 pages per Aim)

Potential pitfalls and alternative strategies

This is a very important part of any proposal. This is where you want to discuss the experiments you propose in Aims 1 and 2. Remember, no experiment is perfect. Are there any reasons why experiments you proposed might not work? Why? What will you do to resolve this? What are other possible strategies you might use if your experiments don’t work? If a reviewer spots these deficiencies and you don’t propose methods to correct them, your proposal will not get funded. You will want to work with your mentor to write this section. (1/2 page per Aim)

Cite all references, including unpublished data from your mentor. Last, First, (year), Title, Journal, volume, pages.

*8 page proposal limit (not including References), 1.5 spacing, 12pt Times New Roman font

• View an example of a research proposal submitted for the Yale College First-Year Summer Research Fellowship (PDF).  
• View an example of a research proposal submitted for the Yale College Dean’s Research Fellowship and the Rosenfeld Science Scholars Program (PDF) .

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Published by Robert Bruce at August 29th, 2023 , Revised On August 12, 2024

Biology Research Topics

Are you in need of captivating and achievable research topics within the field of biology? Your quest for the best biology topics ends right here as this article furnishes you with 100 distinctive and original concepts for biology research, laying the groundwork for your research endeavor.

Table of Contents

Our proficient researchers have thoughtfully curated these biology research themes, considering the substantial body of literature accessible and the prevailing gaps in research.

Should none of these topics elicit enthusiasm, our specialists are equally capable of proposing tailor-made research ideas in biology, finely tuned to cater to your requirements. 

Thus, without further delay, we present our compilation of biology research topics crafted to accommodate students and researchers.

Research Topics in Marine Biology

• Impact of climate change on coral reef ecosystems.
• Biodiversity and adaptation of deep-sea organisms.
• Effects of pollution on marine life and ecosystems.
• Role of marine protected areas in conserving biodiversity.
• Microplastics in marine environments: sources, impacts, and mitigation.

Biological Anthropology Research Topics

• Evolutionary implications of early human migration patterns.
• Genetic and environmental factors influencing human height variation.
• Cultural evolution and its impact on human societies.
• Paleoanthropological insights into human dietary adaptations.
• Genetic diversity and population history of indigenous communities.

Biological Psychology Research Topics 

• Neurobiological basis of addiction and its treatment.
• Impact of stress on brain structure and function.
• Genetic and environmental influences on mental health disorders.
• Neural mechanisms underlying emotions and emotional regulation.
• Role of the gut-brain axis in psychological well-being.

Cancer Biology Research Topics 

• Targeted therapies in precision cancer medicine.
• Tumor microenvironment and its influence on cancer progression.
• Epigenetic modifications in cancer development and therapy.
• Immune checkpoint inhibitors and their role in cancer immunotherapy.
• Early detection and diagnosis strategies for various types of cancer.

Also read: Cancer research topics

Cell Biology Research Topics

• Mechanisms of autophagy and its implications in health and disease.
• Intracellular transport and organelle dynamics in cell function.
• Role of cell signaling pathways in cellular response to external stimuli.
• Cell cycle regulation and its relevance to cancer development.
• Cellular mechanisms of apoptosis and programmed cell death.

Developmental Biology Research Topics 

• Genetic and molecular basis of limb development in vertebrates.
• Evolution of embryonic development and its impact on morphological diversity.
• Stem cell therapy and regenerative medicine approaches.
• Mechanisms of organogenesis and tissue regeneration in animals.
• Role of non-coding RNAs in developmental processes.

Also read: Education research topics

Human Biology Research Topics

• Genetic factors influencing susceptibility to infectious diseases.
• Human microbiome and its impact on health and disease.
• Genetic basis of rare and common human diseases.
• Genetic and environmental factors contributing to aging.
• Impact of lifestyle and diet on human health and longevity.

Molecular Biology Research Topics 

• CRISPR-Cas gene editing technology and its applications.
• Non-coding RNAs as regulators of gene expression.
• Role of epigenetics in gene regulation and disease.
• Mechanisms of DNA repair and genome stability.
• Molecular basis of cellular metabolism and energy production.

Research Topics in Biology for Undergraduates

• 41. Investigating the effects of pollutants on local plant species.
• Microbial diversity and ecosystem functioning in a specific habitat.
• Understanding the genetics of antibiotic resistance in bacteria.
• Impact of urbanization on bird populations and biodiversity.
• Investigating the role of pheromones in insect communication.

Also read: Psychology Research Topics

Synthetic Biology Research Topics 

• Design and construction of synthetic biological circuits.
• Synthetic biology applications in biofuel production.
• Ethical considerations in synthetic biology research and applications.
• Synthetic biology approaches to engineering novel enzymes.
• Creating synthetic organisms with modified functions and capabilities.

Animal Biology Research Topics 

• Evolution of mating behaviors in animal species.
• Genetic basis of color variation in butterfly wings.
• Impact of habitat fragmentation on amphibian populations.
• Behavior and communication in social insect colonies.
• Adaptations of marine mammals to aquatic environments.

Also read: Nursing research topics

Best Biology Research Topics 

• Unraveling the mysteries of circadian rhythms in organisms.
• Investigating the ecological significance of cryptic coloration.
• Evolution of venomous animals and their prey.
• The role of endosymbiosis in the evolution of eukaryotic cells.
• Exploring the potential of extremophiles in biotechnology.

Biological Psychology Research Paper Topics

• Neurobiological mechanisms underlying memory formation.
• Impact of sleep disorders on cognitive function and mental health.
• Biological basis of personality traits and behavior.
• Neural correlates of emotions and emotional disorders.
• Role of neuroplasticity in brain recovery after injury.

Biological Science Research Topics: 

• Role of gut microbiota in immune system development.
• Molecular mechanisms of gene regulation during development.
• Impact of climate change on insect population dynamics.
• Genetic basis of neurodegenerative diseases like Alzheimer’s.
• Evolutionary relationships among vertebrate species based on DNA analysis.

Biology Education Research Topics 

• Effectiveness of inquiry-based learning in biology classrooms.
• Assessing the impact of virtual labs on student understanding of biology concepts.
• Gender disparities in science education and strategies for closing the gap.
• Role of outdoor education in enhancing students’ ecological awareness.
• Integrating technology in biology education: challenges and opportunities.

Biology-Related Research Topics

• The intersection of ecology and economics in conservation planning.
• Molecular basis of antibiotic resistance in pathogenic bacteria.
• Implications of genetic modification of crops for food security.
• Evolutionary perspectives on cooperation and altruism in animal behavior.
• Environmental impacts of genetically modified organisms (GMOs).

Biology Research Proposal Topics

• Investigating the role of microRNAs in cancer progression.
• Exploring the effects of pollution on aquatic biodiversity.
• Developing a gene therapy approach for a genetic disorder.
• Assessing the potential of natural compounds as anti-inflammatory agents.
• Studying the molecular basis of cellular senescence and aging.

Biology Research Topic Ideas

• Role of pheromones in insect mate selection and behavior.
• Investigating the molecular basis of neurodevelopmental disorders.
• Impact of climate change on plant-pollinator interactions.
• Genetic diversity and conservation of endangered species.
• Evolutionary patterns in mimicry and camouflage in organisms.

Biology Research Topics for Undergraduates 

• Effects of different fertilizers on plant growth and soil health.
• Investigating the biodiversity of a local freshwater ecosystem.
• Evolutionary origins of a specific animal adaptation.
• Genetic diversity and disease susceptibility in human populations.
• Role of specific genes in regulating the immune response.

Cell and Molecular Biology Research Topics 

• Molecular mechanisms of DNA replication and repair.
• Role of microRNAs in post-transcriptional gene regulation.
• Investigating the cell cycle and its control mechanisms.
• Molecular basis of mitochondrial diseases and therapies.
• Cellular responses to oxidative stress and their implications in ageing.

These topics cover a broad range of subjects within biology, offering plenty of options for research projects. Remember that you can further refine these topics based on your specific interests and research goals.

Frequently Asked Questions 

What are some good research topics in biology?

A good research topic in biology will address a specific problem in any of the several areas of biology, such as marine biology, molecular biology, cellular biology, animal biology, or cancer biology.

A topic that enables you to investigate a problem in any area of biology will help you make a meaningful contribution. 

How to choose a research topic in biology?

Choosing a research topic in biology is simple. 

Follow the steps:

• Generate potential topics. 
• Consider your areas of knowledge and personal passions. 
• Conduct a thorough review of existing literature.
•  Evaluate the practicality and viability. 
• Narrow down and refine your research query. 
• Remain receptive to new ideas and suggestions.

Who Are We?

For several years, Research Prospect has been offering students around the globe complimentary research topic suggestions. We aim to assist students in choosing a research topic that is both suitable and feasible for their project, leading to the attainment of their desired grades. Explore how our services, including research proposal writing , dissertation outline creation, and comprehensive thesis writing , can contribute to your college’s success.

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Examples of research proposals

How to write your research proposal, with examples of good proposals.

Research proposals

Your research proposal is a key part of your application. It tells us about the question you want to answer through your research. It is a chance for you to show your knowledge of the subject area and tell us about the methods you want to use.

We use your research proposal to match you with a supervisor or team of supervisors.

In your proposal, please tell us if you have an interest in the work of a specific academic at York St John. You can get in touch with this academic to discuss your proposal. You can also speak to one of our Research Leads. There is a list of our Research Leads on the Apply page.

When you write your proposal you need to:

• Highlight how it is original or significant
• Explain how it will develop or challenge current knowledge of your subject
• Identify the importance of your research
• Show why you are the right person to do this research
• Research Proposal Example 1 (DOC, 49kB)
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Thesis proposal example 2

Senior Honors Thesis Research Proposal

Albert B. Ulrich III Thesis Advisor: Dr. Wayne Leibel 11 September 1998

Introduction:

Neotropical fish of the family Cichlidae are a widespread and diverse group of freshwater fish which, through adaptive radiation, have exploited various niches in freshwater ecosystems. One such evolutionary adaptation employed by numerous taxa is miniaturization, an evolutionary process in which a large ancestral form becomes reduced in size to exploit alternative niches. A considerable amount of research has been conducted on the effects of miniaturization on amphibians (Hanken 1983), but although miniaturization has been found to occur in 85 species of freshwater South American fish, little has been done to investigate the effects which miniaturization imposes on the anatomy of the fish (Hanken and Wake 1993).

Background:

Evolution is the process by which species adapt to environmental stresses over time. Nature imposes various selective pressures on ecosystems causing adaptive radiation, where species expand and fill new niches. One such adaptation for a new niche is miniaturization. Miniaturization can be defined as “the evolution of extremely small adult body size within a lineage” (Hanken and Wake 1993). Miniaturization is observed in a variety of taxa, and evolutionary size decreases are observed in mammals and higher vertebrates, but it is more common and more pronounced in reptiles, amphibians and fish (Hanken and Wake 1993). Miniaturization evolved as a specialization which allowed the organisms to avoid selective pressures and occupy a new niche. Miniaturization as a concept is dependent on the phylogenetic assumption that the organism evolved from a larger predecessor. Over time, the miniature organism had to adapt to the new conditions as a tiny species. All of the same basic needs had to be met, but with a smaller body.

In miniature species there is a critical relationship between structure of the body and body size, and frequently this downsizing results in structural and functional changes within the animal (Harrison 1996). Within the concept of miniaturization is the assumption that the species evolved from a larger progenitor. It is necessary then to explore the effects of the miniaturization process. “Miniaturization involves not only small body size per se, but also the consequent and often dramatic effects of extreme size reduction on anatomy, physiology, ecology, life history, and behavior” (Hanken and Wake 1993).

Hanken and Wake 1993 found that the adult skulls of the salamander Thorius were lacking several bones, others were highly underdeveloped, and many species within the genus were toothless. Several invertebrate species display the wholesale loss of major organs systems as a result of the drastic reduction in body size (Hanken and Wake 1993). Hanken and Wake also have shown that morphological novelty is a common result of miniaturization. Morphological novelty, in essence, is the development of new structures in the miniature organism. For example, as body size decreases, certain vital organs will only be able to be reduced by a certain amount and still function. As a result organs such as the inner ear remain large relative to the size of the miniature skull, and structural innovations have to occur in order to support the proportionately large inner ear.

In 1983, James Hanken, at the University of Colorado determined that the adult skull of the Plethodontid salamanders could be characterized by three observations: 1) there was a limited development or even an absence of several ossified elements such as dentition and other bones; 2) there was interspecific and intraspecific variability; 3) there were novel mophological configurations of the braincase and jaw (Hanken 1983).

In his experiments, Hanken found that cranial miniaturization of the Thorius skull was achieved at the expense of ossification. Much of the ossified skeleton was lost or reduced, especially in the anterior elements, which are seen typically in larger adult salamanders (Hanken 1983). In contrast to this ossified downsizing, many of the sensory organs were not diminished in size — therefore present in greater proportion to the rest of the reduced head. He also reported that due to the geometrical space availability, there is a competition for space in reduced sized skulls, and the “predominant brain, otic capsules, and eyes have imposed structural rearrangements on much of the skull that remains” (Hanken 1983).

Hanken proposed that paedomorphosis was the mode of evolution of the plethodontid salamanders (Hanken 1983). Paedomorphosis is the state where the miniaturized structures of the adult salamanders can be described as arrested juvenile states. To support this theory, Hanken showed data where cranial skeletal reduction was less extreme in the posterior regions of the skull. One of the hallmarks of paedamorphosis is the lack of conservation in structures derived late in development. Early developed structures are highly conserved, and the latter derivations become either lost, or greatly reduced. Again, Hanken has shown that elements appearing late in development exhibit greater variation among species than do elements appearing earlier in ontogeny (Hanken 1983). But the presence of novel morphological features cannot be accounted for merely by truncated development and the retention of juvenile traits. Miniature Plethodontid salamanders display features that are not present in other species, juvenile or adult. These novel morphological features are associated with the evolution of decreased size and are postulated to compensate for the reductions occurring in other areas (Hanken 1983).

In 1985, Trueb and Alberch published a paper presenting similar results in their experiments with frogs. They explored the “relationships between body sizes of anurans and their cranial configurations with respect to the degree of ossification of the skull and two ontogenetic variables‹shape and number of differentiation events” (Trueb and Alberch 1985). Trueb and Alberch examined three morphological variables: size, sequence of differentiation events, and shape changes in individual structures. Size and snout length were measured, and the data showed that the more heavily ossified frogs tended to be smaller, whereas the less-ossified species were of average size, contrary to what was hypothesized. But Trueb and Alberch also attributed the diminution in size to paedomorphosis, citing that the smaller frogs lacked one or more of the elements typically associated with anuran skulls‹these missing elements were typically late in the developmental sequence. It is significant to note, however, that although there was an apparent paedomorphic trend, it could not be “applied unequivocally to all anuans” (Trueb and Alberch 1985). Very little research has been done on the effects of miniaturization on fish. In 1993, Buckup published a paper discussing the phylogeny of newly found minature species of Characidiin fish, but the extent of the examination was merely an acknowledgment that the species were indeed miniatures so that they could be taxonomically reclassified ( Buckup 1993). It is this deficit of knowledge with regard to miniaturization in fish that prompts this research.

Statement of the Problem:

How does miniaturization affect other vertebrates, such as fish? There are over 85 species of freshwater South American fish which are regarded as miniature, spanning 5 orders, 11 families and 40 genera (Hanken and Wake 1993). One such species, Apistogramma cacatuoides, is a South American Cichlid native to Peru. It lives in shallow water bodies in the rainforests, where miniature size is necessary. Males in this species reach approximately 8cm, and females only 5cm. This makes A. cacatuoides an ideal specimen for examination. In this senior honors thesis, I intend to examine the effects of miniaturization on cranial morphology of A. cacatuoides.

Plan of Research:

In this thesis, I will compare the cranial anatomy of A. cacatuoides to that of “Cichlasoma” (Archocentrus) nigrofasciatum, a commonly bred fish reared by aquarists known as the Convict Cichlid, a “typical” medium-sized cichlid also of South American origin. The Convicts will be examined at various stages in development, from juvenile to adult, and will be compared to A.cacatuoides.

The first part of this project will involve whole mount preparation of A. cacatuoides, utilizing the staining and clearing procedures described by Taylor and Van Dyke, 1985. This procedure involves the use of Alizarin Red and Alcian Blue to stain bone and cartilage, and takes into account the adaptations and recommendations Proposed in an earlier paper (Hanken and Wassersug 1981). The Taylor and Van Dyke procedure is specifically for the staining and clearing of small fish and other vertebrates. I tested the procedure during last semester¹s Independent Study and made a few minor adjustments to the protocol.

First, the specimens will be placed serially into an absolute ethyl alcohol solution and stained with Alcian Blue. The fish will then be neutralized in a saturated borax solution, transferred to a 20% hydrogen peroxide solution in potassium hydroxide, and then bleached under a fluorescent light. The unwanted soft tissues will then be cleared using trypsin powder, and then stained in KOH again with alizarin red. The final preparation of the fish involves rinsing the fish, and placing them serially into 40%, 70%, and finally 100% glycerin.

Following the above preparation of the specimens, the crania of the A. cacatuoides specimens will be examined for morphological variation and compared to the cranial anatomy of the Convict cichlid as a progenitor reference point examined at various developmental stages to see if paedomorphosis in indeed the mechanism of miniaturization in A. cacatuoides.

Expected Costs:

The project is estimated to cost no more that five hundred dollars for chemicals and supplies for the entire year.

Literature Cited:

Hanken, J., 1983. Miniaturization and its Effects on Cranial Morphology in Plethodontid Salamanders, Genus Thorius (Amphibia: Plethodontidae). I. Osteological Variation”. Biological Journal of the Linnean Society (London) 23: 55-75.

Hanken, James, 1983. Miniaturization and its Effects on Cranial Morhology in Plethodontid Salamanders, Genus Thorius (Amphibia, Plethodintidae): II.The Fate of the Brain and Sense Organs and Their Role in Skull Morphogenesis and Evolution . Journal of Morphology 177: 255-268.

Hanken, James and David Wake, 1993. Miniaturization of Body Size: Origanismal Consequences and Evolutionary Significance. Annual Review of Ecological Systems 24: 501-19.

Harrison, I. J., 1996. Interface Areas in Small Fish. Zoological Symposium No. 69. The Zoological Society of London: London.

Miller, P. J., 1996. Miniature Vertebrates: The Implications of Small Body Size. Symposium of the Zoological Society of London. No. 69: 15-45.

Taylor, William R. and George Van Dyke, 1985. Revised Procedures for Staining and Clearing Small Fishes and Other Vertebrates for Small Bone and Cartilage Study. Cybium. 9(2): 107-119.

Trueb, L. and P. Alberch, 1985. Miniaturization and the Anuran Skull: a Case Study of Heterochrony. Fortschritte der Zoologie. Bund 30.

Williams, T. Walley, 1941 Bone and Cartilage. Stain. Tech. 16:23-25.

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Dissertation Proposal/Preliminary Examination

Doctoral students are expected to complete the Preliminary Examination by the end of their third year in the program. The Preliminary Exam is the defense of a written Dissertation Proposal. The exam will consist of two parts; Part I, approval of the written Dissertation Proposal, and Part II, an oral defense of the proposal before the student’s Ph.D. Advisory Committee.

After the proposal has been approved by the Advisory Committee, the student must submit the Doctoral Dissertation Proposal Hearing Form ( Milestones ) . The student should also request the Doctoral Preliminary Examination Warrant at least three (3) weeks prior to the oral exam date from the Department’s Graduate Program Assistant. The student must also file the Application for the Doctoral Preliminary Examination(s) available in the online doctoral Milestones system. From this application, the Graduate School determines the eligibility of the student to take the Preliminary Examination. The oral defense of the Dissertation Proposal/Preliminary Examination can proceed after approval of the Graduate School, as noted in the Milestones system.

Part I: The Written Dissertation Proposal

Doctoral students must prepare a formal, written Dissertation Proposal outlining the objectives and methodologic approach of his/her proposed research project. A typical proposal is 10-15 single-spaced pages in length exclusive of references. The length of individual Dissertation Proposals may vary depending on the extent of the preliminary results and of the details included in the experimental plan. The proposal must be thorough and of the highest quality. The advisor may assist in formulating the specific aims and research goals of the proposal, but it is expected that the student writes the proposal with subsequent editing assistance from the advisor. The Advisory Committee may provide reviews and literature to assess the student’s understanding of general concepts related to the area of research.

The proposal should include the following sections: 1) Abstract , 2) Background and Significance , 3) Specific Aims , 4) Preliminary Results and 5) Experimental Plan . An Abstract of approximately one page should briefly describe background information pertinent to the research being proposed and mention the unanswered questions the proposal will address. The Background and Significance section will provide background and justification for the questions to be addressed in the dissertation. It should include a discussion of relevant reviews and published literature demonstrating the student’s broad understanding of the central concepts described in the research proposal as well as specialized information pertinent to the specific area of research. The Specific Aims section should concisely summarize the critical questions that the research is intended to answer. In the Preliminary Results section, unpublished results related to the dissertation topic should be described. Research data that establish the importance, relevance, and feasibility of the questions being addressed in the proposal are included in this section. The Experimental Plan should state the hypothesis of each specific aim and describe how the questions raised will be addressed. It should include a description of the approaches and techniques that will be used to conduct the research. The approaches should be described in sufficient detail to illustrate the student’s understanding of the proposed approaches and techniques. The anticipated results should be presented and the significance of the results should be discussed. It is recommended that the proposal include alternative hypotheses/approaches to address unexpected results.

The Dissertation Proposal must be submitted to and approved by the student’s Ph.D. Advisory Committee two weeks before the Preliminary Examination is to be taken.

Part II: Oral Defense of The Dissertation Proposal

The student will give an oral presentation of the Dissertation Proposal to the Ph.D. Advisory Committee. Members of the committee will ask questions during and/or after the presentation. The questions during the exam will focus on the research proposal, but may include any questions or topics relevant to the area of research. The final decision concerning the outcome of the Preliminary Examination will be made by a majority of the Advisory Committee. Once the student has passed the exam he/she must file the signed departmental Doctoral Preliminary Examination Warrant with the Biological Sciences Graduate Program Director.

If a student fails the Preliminary Examination, the Ph.D. Advisory Committee will decide if the student can retake the exam for a second time. If the student fails a second time, a retake is not allowed. For students retaking the Preliminary Examination for the second time, failure of any part (or all) of the examination will result in dismissal from the Graduate Program. The student’s Ph.D. Advisory Committee may appeal to the departmental Graduate Committee to allow a student to retake the exam for the third time. Direct appeals from the student to the departmental Graduate Committee will not be considered.

The student may petition the Graduate School to take only one (1) credit during the semester that he/she intends to take the Preliminary Examination, even while receiving financial support as a TA, PA, RA, or Fellow. To request the one-credit exception, the student must have completed the Application for the Doctoral Preliminary Examination(s) available in the online doctoral Milestones system before the start of the semester. Such a petition will be granted only once during the student’s tenure in the Ph.D. program. The Examining Committee is usually the same as the Ph.D. Advisory committee, but may be any three appropriate UWM graduate faculty or Ph.D. committee members approved by the latter.

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An research proposal examples on biology is a prosaic composition of a small volume and free composition, expressing individual impressions and thoughts on a specific occasion or issue and obviously not claiming a definitive or exhaustive interpretation of the subject.

Some signs of biology research proposal:

• the presence of a specific topic or question. A work devoted to the analysis of a wide range of problems in biology, by definition, cannot be performed in the genre of biology research proposal topic.
• The research proposal expresses individual impressions and thoughts on a specific occasion or issue, in this case, on biology and does not knowingly pretend to a definitive or exhaustive interpretation of the subject.
• As a rule, an essay suggests a new, subjectively colored word about something, such a work may have a philosophical, historical, biographical, journalistic, literary, critical, popular scientific or purely fiction character.
• in the content of an research proposal samples on biology , first of all, the author’s personality is assessed - his worldview, thoughts and feelings.

The goal of an research proposal in biology is to develop such skills as independent creative thinking and writing out your own thoughts.

Writing an research proposal is extremely useful, because it allows the author to learn to clearly and correctly formulate thoughts, structure information, use basic concepts, highlight causal relationships, illustrate experience with relevant examples, and substantiate his conclusions.

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Jabberwocky Ecology

A list of publicly available grant proposals in the biological sciences.

UPDATE: If you’re looking for publicly available grants go check out our new Open Grants website at https://www.ogrants.org/. It has way more grants and is searchable so that you can quickly find the grants most useful to you. Recently a bunch of folks in the biological sciences have started sharing their grant proposals openly. Their…

Ethan White

UPDATE: If you’re looking for publicly available grants go check out our new Open Grants website at https://www.ogrants.org/ . It has way more grants and is searchable so that you can quickly find the grants most useful to you.

Recently a bunch of folks in the biological sciences have started sharing their grant proposals openly . Their reasons for doing so are varied (see the links next to their names below), but part of the common justification is a general interest in opening up science so that all stages of the process can benefit from better interaction and communication, and part of it is to provide examples for younger scientists writing grants. To help accomplish both of these goals I’m going to do what Titus Brown suggested and compile a list of all of the available open proposals in the biological sciences (if you’re looking for math proposals they have a list too). Given the limited number of proposals available at the moment I’m just going to maintain the list here, sorted alphabetically by PI. Another way to find proposals is to look at the ‘grant’ and ‘proposal’ tags on figshare , where several of us have been posting proposals. If you know of more proposals, decide to post some yourself, or have corrections to proposal in the list, just let me know in the comments and I’ll keep the list updated. Enjoy!

B. Arman Aksoy ( @armish )

• 2014 / Postdoctoral fellowships (several) – Making sense of cancer data: Implications for personalized therapy and cancer biology

Casey Bergman ( @caseybergman )

• 2008 / Tools and Resources Development Fund Application – pubmed2ensembl: a resource for linking biological literature to genome sequences (BBSRC) *funded
• 2008 / New Investigator Grant Application (NERC) *funded
• 2008 / EMBO Young Investigator Programme Application (EMBO)
• 2007 / Responsive Mode Grant Application (BBSRC)

Dave Bridges ( @bridges_lab)

• 2014 / Children’s Foundation Research Institute – Prediction of Weight Gain in Inbred Mouse Strains *funded

Titus Brown ( @ctitusbrown ; read Titus’ thoughts on sharing proposals )

• 2012 / NSF Office of Cyberinfrastructure proposal, Materials and Workshops for Cyberinfrastructure Education in Biology supplement to BEACON . *funded
• 2012 / NSF CAREER proposal, Assembling Extremely Large Metagenomes
• 2012 / NSF BIGDATA proposal, Low-memory Streaming Prefilters for Biological Sequencing Data
• 2012 / Moore Foundation proposal on marine metagenomics
• 2011 / NSF CAREER proposal: “Scaling and Improving de Bruijn graph assembly”
• 2010 / Next-gen course (NIH R25) *funded
• 2009 / Web tools for next-gen sequence analysis (USDA) *funded
• 2007 / Cartwheel

Scott Chamberlain ( @recology_ )

• Kathryn Fuller Doctoral Fellowship application (WWF)
• 2010 / Prairie Biotic Research proposal *funded
• 2009 / Ecological and evolutionary impacts of pollinator sharing between cultivated and wild sunflowers (Norman Hackerman Advanced Research Program)
• 2009 /  Lewis and Clark grant proposal (American Philosophical Society)
• Doctoral Dissertation Improvement Grant proposal (NSF)
• Forest Shreeve Award proposal
• Ariel Appleton Research Fellowship Proposal – Ecological Networks
• How do crop-mediated changes in mutualist and antagonist communities affect selection on floral and defense traits?

Endymion D. Cooper ( @EndymionCooper )

• 2015 / Marie Skłodowska-Curie Individual Fellowship *funded

Karen Cranston ( @kcranstn )

• 2011 / “Automated and community synthesis of the tree of life” (NSF AVATOL) *funded
• 2010 / “Towards a comprehensive, community-owned and sustainable repository of reusable phylogenetic knowledge” w/ Hilmar Lapp (NSF ABI)
• 2009 / “A network for enabling community-driven standards to link evolution into the global web of data (EvoIO)” w/ Hilmar Lapp (NSF INTEROP)
• 2009 / NSF Plant Genome *funded

Morgan Ernest ( @skmorgane )

• 2013 / “ Reversing long-term experiments to understand regime shifts ” (NSF DEB preproposal) *funded

Edmund (Ted) Harte ( @DistribEcology )

• 2012 / Understanding range shift model error: The influence of generation time and rate of adaptation on species distribution model predictions . w/ Scott Chamberlain (NCEAS proposal).
• 2008 / Evolution under simulated climate change in response to trophic shifts . (NSF DDIG) *funded

Tanja Pyhäjärvi

• 2010 / Finnish Academy: Population genomics of Zea mays spp. parviglumis – natural selection from the species to the genome *funded

Jan Jensen ( @ janhjensen ; read Jan’s thoughts on sharing proposals )

• 2010 / Protein Design Using Quantum Mechanics (Danish Center for Supercomputing) *funded
• 2008 / Computational Design of Stable Enzymes (Danish National Science Foundation, DSF-NABIIT) *funded
• 2006 / Modeling pH-Dependence in Drug Design (EU Marie Curie Program) *funded
• 2006 / Computational Prediction and Validation of Protein Structure and Function in Protein Engineering and Rational Drug Design (Danish National Science Foundation, FNU) *funded
• 2006 / Prediction and Interpretation of Protein pKa’s Using QM/MM (US National Science Foundation – MCB; rescinded when I moved to Denmark) *funded
• 2002 / The Prediction and Interpretation of Protein pKa’s Using QM/MM (US National Science Foundation – MCB) *funded

Paula Mabee

• 2010 / Ontology-enabled reasoning across phenotypes from evolution and model organisms w/Todd Vision (NSF) *funded

Rod Page ( @ rdmpage ; read Rod’s thoughts on sharing proposals )

• 2011 / Dark taxa: Preparing for a post-taxonomic future

David Pappano ( @djpappano )

• 2013 / NSF Postdoctoral Research Fellowship in Biology
• 2010 / Leakey Foundation General Research Grant
• 2009 / US Student Fulbright
• 2009 / NSF Dissertation Improvement Grant

Heather Piwowar ( @ researchremix ) & Jason Priem ( @jasonpriem ) (read their thoughts on sharing proposals )

• 2011 / Total-impact development proposal , Original submission (Sloan Foundation) *funded

Rosie Redfield ( @RosieRedfield )

• Uptake proposal (CIHR)
• 2007 / Sxy proposal (CIHR) *funded
• 2001 / CIHR proposal *funded
• 1999 / NIH proposal *funded

Andrey Revyakin

• Case for support: Single molecule dynamics of human transcription regulatio n *funded

Jeff Ross-Ibarra

• 2009 / USDA/NIFA: “Scanning for yield: high-throughput discovery of candidate agronomic loci for marker-assisted selection in maize” *funded
• 2015 / NSF Plant Genome Research Program: “The genetics of highland adaptation in maize” *funded

Menno Schilthuizen ( @schilthuizen )

• Netherlands organization for scientific research postdoc fellowship
• Netherlands organization for scientific research PhD fellowship
• Netherlands organization for scientific research PhD fellowship *funded
• Netherlands organization for scientific research postdoc fellowship *funded

Delia S. Shelton

• 2010 / NSF Graduate Research Fellowship *funded
• 2016 / NSF Postdoctoral Fellowship *funded ( associated reviews )

Andrew Su ( @andrewsu )

• 2014 / Gene Wiki: Expanding the ecosystem of community intelligence resources (R01 GM089820)
• 2017 / Gene Wiki renewal

Sarah Supp ( @srsupp )

• 2014 / Dynamic macroecology: Globally assessing body size diversity response to environmental change (NSF Postdoctoral Fellowship) *funded

Tracy Teal ( @tracykteal )

• 2012 / Data Management and Computational Skills Training for LTER Scientists w/ Ethan White & Greg Wilson (LTER Training Working Groups Proposal)

Andrew Tredennick ( @ATredennick )

• 2011 / Fuelwood, Savannas, and Climate Change: Integrating Modeling, Field Experimentation, and Optical and Radar Remote Sensing (NASA Predoctoral Graduate Fellowship) *funded
• 2014 / NSF Postdoctoral Fellowship – Diversity-stability relationships and coexistence: new theory and empirical tests   *funded

Heroen Verbruggen

• 2012 / Genomic tools to study coral reef resilience (University of Melbourne)
• 2012 / Plastid endosymbiosis: a detailed study of genome dynamics (Australian Research Council)
• 2012 / Evolutionary dynamics of the algae: Understanding adaptive potential under environmental change (Australian Research Council) *funded
• Probing key innovations with next generation sequencing
• 2009 / Macroevolutionary dynamics of marine algae

Todd Vision ( @tjvision )

• 2012 / Sustainable and Scalable Infrastructure for the Publication of Data (NSF) *funded
• 2008 / A Digital Repository for Preservation and Sharing of Data Underlying Published Works in Evolutionary Biology (NSF) *funded

Detlef Weigel ( @PlantEvolution )

• 2013 /  ERC AdG IMMUNENESIS *funded

Ethan White ( @ethanwhite ; read Ethan’s thoughts on sharing proposals )

• 2014 / Moore Investigator in Data Driven Discovery proposal *funded
• 2010 / CAREER: Advancing Macroecology Using Informatics and Entropy Maximization (NSF CAREER Award) *funded
• 2005 / Broad-scale patterns of the distribution of body sizes of individuals in ecological communities (NSF Postdoc Fellowship) *funded
• 2008 / Understanding multimodality in animal size distributions (NSF Research Starter Grant) *funded

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49 responses to “a list of publicly available grant proposals in the biological sciences”.

UPDATE: Apparently I got distracted by my toddler last night before adding in all of the twitter handles for folks who have made grants available. That has now been corrected.

It’s also worth noting that because this is a list I’ll keep updating the post and to make things easier I’ll just note updates in the comments rather than attempting to keep a change log in the post itself.

Thanks for putting this together Ethan! And for inspiring me to join in.

Here are three of mine (Karen Cranston, @kcranstn) * NSF AVATOL 2011, “Automated and community synthesis of the tree of life”, http://opentree.wikispaces.com/Grant+Proposal * NAF ABI 2010, “Towards a comprehensive, community-owned and sustainable repository of reusable phylogenetic knowledge”, http://www.evoio.org/wiki/ABI_2011_proposal * NSF INTEROP 2009, “A network for enabling community-driven standards to link evolution into the global web of data (EvoIO)”, http://www.evoio.org/wiki/NSF_INTEROP_2009

Thanks Karen! I justed added them to the main post.

UPDATE: More proposals by Scott Chamberlain added.

BTW @kcranstn’s AVAToL proposal is funded. (The other two are not – oddly those are the ones I’m co-PI on…)

The Dryad proposals (PI: @tjvision) have been available (and both were/are funded): http://wiki.datadryad.org/NSF_grant_2008-2012 http://wiki.datadryad.org/NSF_grant_2012-2016

The current Phenoscape grant (PIs: P. Mabee and @tjvision) has been, too: http://phenoscape.org/wiki/File:Phenoscape_Project_description_refs.pdf

I thought the first one had been too, but I can’t find it posted now.

Thanks Hilmar! I just added all of that information to the main post.

Ethan, very useful list. I posted some of my proposals here: http://phycoweb.net/projects/projects.html

Thanks Heroen! I’ve just updated the list with your grants.

[…] you try your luck with that Post-Doc grant proposal, check out some of these other Biology grant proposals that researchers have made publicly available (I especially like that they’ve noted which were actually […]

[…] biology researcher Ethan White has compiled a list of publicly available grant proposals in the biological sciences (thanks to Phil Ward for highlighting this). Often university research offices make available […]

Added Ted Harte’s funded NSF DDIG.

UPDATE: Just added Tracy Teal’s LTER Training Workshop proposal (with Greg Wilson and myself).

UPDATE: Added Andrew Tredennick’s funded NASA predoc proposal. UPDATE to comment: correctly indicated both here and in the page that is was a predoc proposal.

UPDATE: Added Ted Hart and Scott Chamberlain’s NCEAS proposal. Thanks guys!

[…] resources, including this set of slides by Russ Altman at Stanford (thanks, @andrewsu!) and a list of publicly avilable grant proposals in the biological sciences by Jabberywocky Ecology. If you’re interested in reading more about […]

Don’t know if any of you have considered this, but you need a signed FERPA release to post the names of any students (including grad) and/or postdocs publicly, as in these grant proposals.

UPDATE: Added David Pappano’s grants.

Please find attached link to my Case of Support. It got funded by the BBSRC.

http://www2.le.ac.uk/departments/biochemistry/staff/Andrey%20Revyakin/research/papers/6_Case_Of_Support_Main_Text_Only.pdf

Thanks Andrey – done!

UPDATE: Added Andrey Revyakin’s grant.

[…] limitations, but the general themes and goals are still relevant. I’ve benefited from reading proposals that other people have shared, so I thought it was time to share some of […]

[…] see. This is in keeping with a new philosophy of science transparency, and there are some excellent lists of publicly available grant proposals. Hopefully, this helps you understand what goes into the beginnings of a research project, after […]

UPDATE: Added Morgan Ernest’s preproposal.

Just posted one of mine… http://figshare.com/articles/Gene_Wiki_Expanding_the_ecosystem_of_community_intelligence_resources_R01_GM089820_/1242817

Thanks @andrewsu. It’s been added.

UPDATE: Added Andrew Su’s Gene Wiki proposal and Ethan White’ Moore Investigator in Data Driven Discovery proposal.

UPDATE: Added proposals by Dave Bridges and Arman Aksoy.

Good ide; I’ve just posted five of my grant proposals on Figshare: http://figshare.com/authors/Menno_Schilthuizen/662106

Thanks for sharing @schilthuizen! I’ve added your grants to the list.

Added Sarah Supp’s funded NSF Postdoctoral Fellowship proposal.

[…] number of scientists that are sharing their grant proposals – check out a list for Ecology here. Openly sharing grant proposals has been discussed recently in some great posts by other ecologists […]

Reblogged this on It's not easy to be a PhD and commented: Useful stuff…

The NIH posted several helpful example proposals here: http://www.niaid.nih.gov/researchfunding/grant/pages/appsamples.aspx

Thanks Anne!

[…] for public viewing, then I’d post them on my website. And this is something that people have done. Thanks for the altruism! (Meanwhile, I feel like research programs at my university need to […]

My successful Marie Skłodowska-Curie Individual Fellowship Proposal is here: http://dx.doi.org/10.6084/m9.figshare.1456169

Thanks Endymion! I’ve added it to the list.

UPDATE: Added Endymion Cooper’s fellowship to the list.

Update: Added Delia Shelton NSF Graduate Research Fellowship. Thanks Delia!

[…] Jabberwocky Ecology: Links to proposals in the biological sciences, most submitted to government agencies. […]

[…] the grants, and unknowingly joined a really awesome cadreof folk who had already done the same( http://jabberwocky.weecology.org/2012/08/10/a-list-of-publicly-available-grant-proposals-in-the-biol&#8230 ;).Most feedback I’ve gotten has been from grad students and undergradswho really appreciate the […]

[…] Lista de propostas de concessão de acesso público  […]

[…] left people off the list like Titus and Ethan who have gone all in, even posting their grants online. I did this because they are very loud advocates of open science, but I wanted to highlight quieter […]

Grants here: https://github.com/RILAB/statements

Ross – thanks for the contribution and sorry for the delay in getting it up. I’ve posted all of the grants at that link that I had enough metadata about.

Update: Added Delia Sehlton’s NSF Postdoctoral Fellowship proposal and associated reviews.

Update: Added Andrew Tredenick’s funded NSF postdoc proposal.

Hi there, check out the many proposals, CVs, etc at the Broad/MIT CommKit; plus nice guidance on writing: http://mitcommlab.mit.edu/broad/use-the-commkit/

[…] to all. Others have joined him in this, and he has compiled the beginnings of a list of ‘publicly available grant proposals in the biological sciences‘. There’s also one for the mathematical sciences, too. These have now led to the […]

Hello, I was trying to access David Pappano’s Leakey Foundation grant but seems like the link is broken. Is there any other place I could access it by chance? Thank you so much for creating this wonderful website! It is really helpful for early career researchers such as myself.

Thanks for your patience. All of the open grants work has moved to https://www.ogrants.org/ which has all of the most up to date information. Unfortunately it looks like that proposal isn’t there, probably because the link broke at some point and we couldn’t reach the original poster to get it put back on the web.

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Wayne State-led research helps uncover therapies for Barth Syndrome's deadly cardiac and skeletal effects

Joined by two collaborators, Wayne State Biological Sciences Professor Miriam Greenberg has received an NIH award to develop new treatments of Barth Syndrome . This genetic disease inflicts severe cardio/skeletal myopathy which limits the quality of life or even causes premature death.

Effective Barth Syndrome therapies are lacking due to an incomplete understanding of precisely which misregulated mechanisms lead to its symptoms. The project combines the expertise of Miriam Greenberg in the molecular genetics cardiolipin production with the expertise of Dr. Valerian Kagan in redox biology (University of Pittsburgh) and Hülya Bayir in redox lipidomics and MS-imaging (Columbia University).

The research team will conduct a search for drugs that cure a pathogenic effect of BTHS which has not yet been targeted. In previous work, the team discovered a new aspect in the biochemical processing of the essential and unique mitochondrial phospholipid, cardiolipin. Their efforts established that a remodeling intermediate, monolysocardiolipin, forms an aberrant complex with a Fe-protein, cytochrome c, with a calamitous new pro-oxidant function of a peroxidase, which triggers massive and toxic lipid peroxidation.

The new funding will allow to search for potent and selective inhibitors of the monolysocardiolipin-mediated peroxidase activity to treat the devastating effects of Barth syndrome.

Faculty spotlight

• Miriam Greenberg

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