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COMMENTS

  1. Nature Reviews Drug Discovery

    Nature Reviews Drug Discovery is a journal for people interested in drug discovery and development. It features reviews, news, analysis and research highlights.

  2. Drug discovery

    Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology. We developed ...

  3. Drug Design and Discovery: Principles and Applications

    Drug discovery is the process through which potential new therapeutic entities are identified, using a combination of computational, experimental, translational, and clinical models (see, e.g., [1,2]).Despite advances in biotechnology and understanding of biological systems, drug discovery is still a lengthy, costly, difficult, and inefficient process with a high attrition rate of new ...

  4. Drug discovery

    Synthetic drug kills fungi but spares kidney cells. Amphotericin B is a clinically vital antifungal drug, but it has high renal toxicity. The compound kills cells by forming sponge-like aggregates ...

  5. Drug Repurposing: An Effective Tool in Modern Drug Discovery

    Drug repurposing is the technique of using an existing drug or drug candidate for a new treatment or medical condition for which it was not indicated before [ 1 ]. It was initially developed to treat a different medical condition. It has been described as a serendipitous process that happens unexpectedly. In this process, the undesired side ...

  6. A comprehensive review of discovery and development of drugs discovered

    1. Introduction. Drug discovery and development is a process that involves the identification, optimization, pre-clinical and clinical studies to extensively test and characterize the new drug molecule for its pharmacological properties and toxicity profile (Sleire et al., 2017).After the successful completion of the Human Genome project in 2003, a rough draft of the human genome has been ...

  7. Frontiers in Drug Discovery

    A multidisciplinary journal that focuses on drug discovery and the development lifecycle, from the identification of drug entities to the design and development of new candidate medications and the...

  8. Full article: Artificial intelligence in drug discovery: recent

    Research in this direction is expected to intensify in the near future, opening up fresh modeling opportunities. ... Article highlights Ligand-based drug discovery built on novel deep learning techniques, such as message-passing neural networks, could facilitate the discovery of new chemical entities.

  9. Drug Development Research

    Drug Development Research is an interdisciplinary pharmacology journal publishing papers and reviews covering all areas of drug development, including medicinal and process chemistry, biotechnology and biopharmaceuticals, toxicology, drug delivery, formulation, pharmacokinetics, and clinical trial reviews. Since 1981, we serve a diverse research community including pharmacologists, pharmacists ...

  10. A smarter way to streamline drug discovery

    Coley is joined on the paper by lead author Jenna Fromer SM '24. The research appears today in Nature Computational Science. Complex cost considerations. In a sense, whether a scientist should synthesize and test a certain molecule boils down to a question of the synthetic cost versus the value of the experiment.

  11. Drugs, Brains, and Behavior: The Science of Addiction

    At the National Institute on Drug Abuse (NIDA), we believe that increased understanding of the basics of addiction will empower people to make informed choices in their own lives, adopt science-based policies and programs that reduce drug use and addiction in their communities, and support scientific research that improves the Nation's well ...

  12. Research articles

    This article presents a detailed analysis, based on comprehensive, recent, industry-wide data, to identify the relative contributions of each of the steps in the drug discovery and development ...

  13. Drug Research

    Applies for Individuals only. Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine ...

  14. Substance Use Disorders and Addiction: Mechanisms, Trends, and

    The numbers for substance use disorders are large, and we need to pay attention to them. Data from the 2018 National Survey on Drug Use and Health suggest that, over the preceding year, 20.3 million people age 12 or older had substance use disorders, and 14.8 million of these cases were attributed to alcohol.When considering other substances, the report estimated that 4.4 million individuals ...

  15. Drug discovery and development: Role of basic biological research

    This article provides a brief overview of the processes of drug discovery and development. Our aim is to help scientists whose research may be relevant to drug discovery and/or development to frame their research report in a way that appropriately places their findings within the drug discovery and development process and thereby support effective translation of preclinical research to humans.

  16. Journal of Drug Issues: Sage Journals

    Journal of Drug Issues (JDI), published quarterly, has been dedicated since its inception to providing a professional and scholarly forum centered on the national and international problems associated with drugs, especially illicit drugs.It is a refereed publication with international contributors and subscribers. As a leader in its field, JDI is an instrument widely used by research scholars ...

  17. Advances in understanding addiction treatment and recovery

    This collection includes comprehensive review articles on these substances authored by leading researchers in the field of addiction, along with research studies that present recent discoveries with clear translational impact on developing new treatment targets and effective intervention strategies. ... Other drug-overdose deaths have increased ...

  18. Revolutionizing drug discovery: an AI-powered transformation of

    AI-based molecular docking is a computational technique that utilizes artificial intelligence (AI) algorithms to enhance the accuracy and efficiency of molecular docking simulations [].Molecular docking is a crucial tool in drug discovery and design, enabling researchers to predict how a small molecule (ligand) interacts with a target protein (receptor) at the atomic level [].

  19. Tapping into the drug discovery potential of AI

    Tapping into the drug discovery potential of AI. Plentiful financing and multiple pharma partnerships illustrate the burgeoning interest in applying artificial intelligence tools to drug research ...

  20. Drug Use

    More than 100,000 Americans die every year from drug overdoses. We should warn people in real time about dangerous adulterants in the illicit drug market. Edward Sisco. Drug Use August 2, 2023.

  21. Leqembi and Alzheimer's: What to Know About the New Drug, Treatment and

    As the F.D.A. considers a new Alzheimer's medication, we asked experts how the rollout of a similar drug has gone. By Dana G. Smith Over the last three years, a new class of Alzheimer's drug ...

  22. Addiction as a brain disease revised: why it still matters, and the

    Introduction. Close to a quarter of a century ago, then director of the US National Institute on Drug Abuse Alan Leshner famously asserted that "addiction is a brain disease", articulated a set of implications of this position, and outlined an agenda for realizing its promise [].The paper, now cited almost 2000 times, put forward a position that has been highly influential in guiding the ...

  23. Savings on Generic Drugs Through the Mark Cuban Cost Plus Drug Company

    Our findings are consistent with an analysis of Costco's direct-to-consumer pharmacy, which found that higher spending occurred in 11% of Medicare Part D claims. 4 In contrast, an analysis of the 20 most-prescribed generic drugs found that out-of-pocket costs for 20% of prescriptions exceeded prices for Prime members at Amazon Pharmacy. 5 ...

  24. Substance Abuse and Public Health: A Multilevel Perspective and

    1. Introduction. It is apparent that substance abuse is a cross-disciplinary topic of research and concern [1,2], which involves the need to employ concomitantly various theoretical explications and empirical evidence in collaborative efforts to strive for more optimal solutions to limit its contagiousness, and to curb any direct and indirect harm [3,4].

  25. To treat obesity in kids, task force favors behavior therapy over drugs

    It's less than clear for the four drugs discussed in the task force's analysis of current research, she said. The drugs are semaglutide (sold as Wegovy for weight loss/Ozempic for diabetes ...

  26. Pharmacology

    Pharmacology articles from across Nature Portfolio. Pharmacology is a branch of biomedical science, encompassing clinical pharmacology, that is concerned with the effects of drugs/pharmaceuticals ...

  27. Black Americans' mistrust of the criminal justice system

    Views about the intentions of the U.S. criminal justice system have their roots in key events in the 20th century. In the convict-leasing and chain gang systems of the early 1900s, Black men were forced to build roads, bridges and ditches as part of their incarceration. This new infrastructure improved the business prospects of rural planters throughout the South.

  28. Clinical Trials and Clinical Research: A Comprehensive Review

    Clinical research can also be classified into non-directed data capture, directed data capture, and drug trials. Clinical research could be prospective or retrospective. It may also be a case-control study or a cohort study. Clinical trials may be initiated to find treatment, prevent, observe, and diagnose a disease or a medical condition. ...

  29. Addiction as a brain disease revised: why it still matters, and the

    J Stud Alcohol Drugs. 2015;76:773-80. Article PubMed ... National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of ...

  30. KFF Health Tracking Poll May 2024: The Public's Use and Views of GLP-1

    Key Findings. The latest KFF Health Tracking Poll finds that about one in eight adults (12%) say they have ever taken a GLP-1 agonist - an increasingly popular class of prescription drugs used ...