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You Can Learn Anything Through Reverse Engineering

• Ron Friedman

Greatness comes from more than talent and practice.

To reverse engineer is to look beyond what is evident on the surface and find a hidden structure — one that reveals both how an object or idea was designed and, more important, how it can be re-created. It facilitate skill acquisition in any field and is especially useful for knowledge workers whose success depends on their ability to learn quickly and adapt to rapidly evolving fields. Here are three practical steps you can use to elevate your skills by reverse engineering exceptional works in your field.

• Become a collector.  The first step to learning through reverse engineering is starting a collection of outstanding examples that are worth analyzing.
• Spot the difference.  By comparing the exceptional works in your collection against average works that you chose not to include, you can identify critical ingredients that make them distinctive.
• Score your performance.  Develop metrics that help you assess your own performance when attempting to recreate the features that make the works in your collection exceptional.

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Throughout our lives, we’ve been told two major stories about how top performers, like Simone Biles, Steve Jobs, and Barack Obama, achieve at the highest levels.

• RF Ron Friedman , PhD, is an award-winning psychologist and the founder of ignite80 , a learning and development company that teaches leaders science-based strategies for building high-performing teams. His books include The Best Place to Work: The Art and Science of Creating an Extraordinary Workplace , and more recently,   Decoding Greatness: How the Best in the World Reverse Engineer Success . To receive an email when he posts a new article, click here .

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Reverse Engineering the Brain Based on Machine Learning

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• First Online: 02 October 2020
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• S. A. Shumsky 6 , 7  

Part of the book series: Studies in Computational Intelligence ((SCI,volume 925))

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• International Conference on Neuroinformatics

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A research program is proposed for developing human-like AGI. The top-down strategy of reverse engineering the brain architecture is complemented with the bottom-up machine learning approach. Narrow AI based on deep neural networks mimics low-level conditional reflexes. General intelligence is supposed to have higher-level computational architecture of artificial psyche, possessing inner motivations to explore and model complex environment. Such an architecture may be borrowed from the brain. Namely, by reverse engineering cortico-striatal system of mammalian brain we developed a hierarchical reinforcement learning model, capable of learning complex behavior with an arbitrary large planning horizon. The latter extends simple models of artificial psyche of animats, like MicroPsi2, providing the next step on the “animat path to AGI”. We argue that research should focus on modeling the architecture of the brain in terms of machine learning.

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P.N.Lebedev Physical Institute, Moscow, Russia

S. A. Shumsky

Moscow Institute of Physics and Technology, Moscow, Russia

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Scientific Research Institute for System Analysis, Russian Academy of Sciences, Moscow, Russia

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Moscow Aviation Institute (National Research University), Moscow, Russia

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Shumsky, S.A. (2021). Reverse Engineering the Brain Based on Machine Learning. In: Kryzhanovsky, B., Dunin-Barkowski, W., Redko, V., Tiumentsev, Y. (eds) Advances in Neural Computation, Machine Learning, and Cognitive Research IV. NEUROINFORMATICS 2020. Studies in Computational Intelligence, vol 925. Springer, Cham. https://doi.org/10.1007/978-3-030-60577-3_1

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Published : 02 October 2020

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Jamshidi earns recognition for most influential paper

When someone in academia publishes a research paper, one of the goals is to have the paper cited by other professors and researchers. A paper published 10 years ago by Computer Science and Engineering Assistant Professor Pooyan Jamshidi was recently recognized for its significant impact.

Jamshidi received the Most Influential Paper Award in April at the 19th International Conference on Software Engineering for Adaptive and Self-Managing Systems (SEAMS) in Lisbon, Portugal. Jamshidi’s paper, “ Autonomic Resource Provision for Cloud-based Software ,” was submitted, accepted and published just prior to earning his Ph.D. from Dublin City University in Ireland in 2014. It was presented at the 2014 SEAMS Conference in India.

For the most influential paper award, a select committee considers conference publications published approximately 10 years previously and selects those that have made the most impact according to several criteria, including the number of citations, practical applications and industry adoption, and influence on subsequent research. The most influential award is selected from this short list.

“I wanted to publish the most important part of my Ph.D. research at SEAMS because it was a special community, and their work was close to mine,” Jamshidi says. “Receiving this award is important because this was my first paper with the community. I kept publishing with SEAMS and remained engaged.” 

The paper’s title referred to a groundbreaking approach to fundamentally transform how resources are managed and allocated in cloud environments. The key innovation was to enable multiple tenants to describe their adaptation rules for cloud and multi-cloud resource provisioning using a specific language that enables the incorporation of reasoning, inference and resolution of conflicting adaptation rules.

Since the paper was published, it has received 188 citations according to Google Scholar . In addition, the autonomic resource provision technique has been integrated with Microsoft Azure and OpenStack . The concepts and methods introduced in the paper have also led to follow-up research in cloud autoscaling, Edge-and-Internet of Things resource scaling, and networking and autonomous driving.

The paper has impacted the field of software engineering, especially in the context of adaptive and self-managing systems in the cloud, research, industry practices and the broader technological landscape.

While Jamshidi admits that autonomous autoscaling system for cloud-based software is not as a hot topic as it was when his paper was published, it is still a relevant research area that is leading to new ideas, methods, and approaches.

“The most exciting direction in cloud auto-scaling and resource provisioning overall is sustainability-aware approaches to enable sustainable computer usage for modern applications, such as AI systems,” Jamshidi says. “We plan to continue this line of research. For example, thanks to funds provided by the National Science Foundation and collaborators from Carnegie Mellon University and Rochester Institute of Technology, we are investigating software-driven sustainability.” 

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New treatment could reverse hair loss caused by an autoimmune skin disease

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Researchers at MIT, Brigham and Women’s Hospital, and Harvard Medical School have developed a potential new treatment for alopecia areata, an autoimmune disorder that causes hair loss and affects people of all ages, including children.

For most patients with this type of hair loss, there is no effective treatment. The team developed a microneedle patch that can be painlessly applied to the scalp and releases drugs that help to rebalance the immune response at the site, halting the autoimmune attack.

In a study of mice, the researchers found that this treatment allowed hair to regrow and dramatically reduced inflammation at the treatment site, while avoiding systemic immune effects elsewhere in the body. This strategy could also be adapted to treat other autoimmune skin diseases such as vitiligo, atopic dermatitis, and psoriasis, the researchers say.

“This innovative approach marks a paradigm shift. Rather than suppressing the immune system, we’re now focusing on regulating it precisely at the site of antigen encounter to generate immune tolerance,” says Natalie Artzi, a principal research scientist in MIT’s Institute for Medical Engineering and Science, an associate professor of medicine at Harvard Medical School and Brigham and Women’s Hospital, and an associate faculty member at the Wyss Institute of Harvard University.

Artzi and Jamil R. Azzi, an associate professor of medicine at Harvard Medical School and Brigham and Women’s Hospital, are the senior authors of the new study , which appears in the journal Advanced Materials . Nour Younis, a Brigham and Women’s postdoc, and Nuria Puigmal, a Brigham and Women’s postdoc and former MIT research affiliate, are the lead authors of the paper.

The researchers are now working on launching a company to further develop the technology, led by Puigmal, who was recently awarded a Harvard Business School Blavatnik Fellowship.

Direct delivery

Alopecia areata, which affects more than 6 million Americans, occurs when the body’s own T cells attack hair follicles, leading the hair to fall out. The only treatment available to most patients — injections of immunosuppressant steroids into the scalp — is painful and patients often can’t tolerate it.

Some patients with alopecia areata and other autoimmune skin diseases can also be treated with immunosuppressant drugs that are given orally, but these drugs lead to widespread suppression of the immune system, which can have adverse side effects.

“This approach silences the entire immune system, offering relief from inflammation symptoms but leading to frequent recurrences. Moreover, it increases susceptibility to infections, cardiovascular diseases, and cancer,” Artzi says.

A few years ago, at a working group meeting in Washington, Artzi happened to be seated next to Azzi (the seating was alphabetical), an immunologist and transplant physican who was seeking new ways to deliver drugs directly to the skin to treat skin-related diseases.

Their conversation led to a new collaboration, and the two labs joined forces to work on a microneedle patch to deliver drugs to the skin. In 2021, they reported that such a patch can be used to prevent rejection following skin transplant. In the new study, they began applying this approach to autoimmune skin disorders.

“The skin is the only organ in our body that we can see and touch, and yet when it comes to drug delivery to the skin, we revert to systemic administration. We saw great potential in utilizing the microneedle patch to reprogram the immune system locally,” Azzi says.

The microneedle patches used in this study are made from hyaluronic acid crosslinked with polyethylene glycol (PEG), both of which are biocompatible and commonly used in medical applications. With this delivery method, drugs can pass through the tough outer layer of the epidermis, which can’t be penetrated by creams applied to the skin.

“This polymer formulation allows us to create highly durable needles capable of effectively penetrating the skin. Additionally, it gives us the flexibility to incorporate any desired drug,” Artzi says. For this study, the researchers loaded the patches with a combination of the cytokines IL-2 and CCL-22. Together, these immune molecules help to recruit regulatory T cells, which proliferate and help to tamp down inflammation. These cells also help the immune system learn to recognize that hair follicles are not foreign antigens, so that it will stop attacking them.

Hair regrowth

The researchers found that mice treated with this patch every other day for three weeks had many more regulatory T cells present at the site, along with a reduction in inflammation. Hair was able to regrow at those sites, and this growth was maintained for several weeks after the treatment ended. In these mice, there were no changes in the levels of regulatory T cells in the spleen or lymph nodes, suggesting that the treatment affected only the site where the patch was applied.

In another set of experiments, the researchers grafted human skin onto mice with a humanized immune system. In these mice, the microneedle treatment also induced proliferation of regulatory T cells and a reduction in inflammation.

The researchers designed the microneedle patches so that after releasing their drug payload, they can also collect samples that could be used to monitor the progress of the treatment. Hyaluronic acid causes the needles to swell about tenfold after entering the skin, which allows them to absorb interstitial fluid containing biomolecules and immune cells from the skin.

Following patch removal, researchers can analyze samples to measure levels of regulatory T cells and inflammation markers. This could prove valuable for monitoring future patients who may undergo this treatment.

The researchers now plan to further develop this approach for treating alopecia, and to expand into other autoimmune skin diseases.

The research was funded by the Ignite Fund and Shark Tank Fund awards from the Department of Medicine at Brigham and Women’s Hospital.

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Press mentions, healthday news.

MIT researchers have developed microneedle patches that are capable of restoring hair growth in alopecia areata patients, reports Ernie Mundell for HealthDay . The team’s approach includes a, “patch containing myriad microneedles that is applied to the scalp,” writes Mundell. “It releases drugs to reset the immune system so it stops attacking follicles.” 

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