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Three-year mortality of ICU survivors with sepsis, an infection or an inflammatory illness: an individually matched cohort study of ICU patients in the Netherlands from 2007 to 2019
Sepsis is a frequent reason for ICU admission and a leading cause of death. Its incidence has been increasing over the past decades. While hospital mortality is decreasing, it is recognized that the sequelae o...
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The effects between andexanet alpha and four-factor prothrombin complex concentrate on DOACs anticoagulation reversal
How to define parenteral nutrition, pitfall of lung ultrasound in the quantification of pneumothorax, inhalation no in the hfnc group may result in a meaningless extension of survival time.
The original article was published in Critical Care 2024 28 :344
Volatile anaesthetics for ICU sedation: beyond hypnosis?
The original article was published in Critical Care 2024 28 :269
The long-term conditional mortality rate in older ICU patients compared to the general population
Understanding how preexisting comorbidities may interact with a critical illness is important for the assessment of long-term survival probability of older patients admitted to the ICU.
Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis
Fever is a common condition in intensive care unit (ICU) patients, with an incidence between 30 and 50% in non-neurological ICU patients and up to 70–90% in neurological ICU patients. We aim to perform systema...
Predictors of weaning failure in ventilated intensive care patients: a systematic evidence map
Ventilator weaning is of great importance for intensive care patients in order to avoid complications caused by prolonged ventilation. However, not all patients succeed in weaning immediately. Their spontaneou...
Based -evidence, an intervention study to improve sleep quality in awake adult ICU patients: a prospective, single-blind, clustered controlled trial
Evidence-based guidelines advocate promoting sleep in intensive care unit (ICU) patients, yet many patients experience poor sleep quality. We sought to develop a collaborative evidence-based intervention with ...
Epidemiology of β -blocker use among critically iII patients during and after septic shock
Representation of intensivists’ race/ethnicity, sex, and age by artificial intelligence: a cross-sectional study of two text-to-image models.
Integrating artificial intelligence (AI) into intensive care practices can enhance patient care by providing real-time predictions and aiding clinical decisions. However, biases in AI models can undermine dive...
Factors of prolonged-grief-disorder symptom trajectories for ICU bereaved family surrogates
Bereaved people experience distinct trajectories of prolonged-grief-disorder (PGD) symptoms. A few studies from outside critical care investigated limited factors of PGD-symptom trajectories without a theoreti...
Length of hospital and intensive care unit stay in patients with invasive candidiasis and/or candidemia treated with rezafungin: a pooled analysis of two randomised controlled trials
Invasive candidiasis/candidemia (IC/C) is associated with a substantial health economic burden driven primarily by prolonged hospital stay. The once-weekly IV echinocandin, rezafungin acetate, has demonstrated...
Changes in central venous-to-arterial PCO 2 difference and central venous oxygen saturation as markers to define fluid responsiveness in critically ill patients: a pot-hoc analysis of a multi-center prospective study
The main aim of the study whether changes in central venous-to-arterial CO 2 difference (ΔP(v–a)CO 2 ) and central venous oxygen saturation (ΔScvO 2 ) induced by volume expansion (VE) are reliable parameters to define...
The efficacy of fiber-supplemented enteral nutrition in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
Evidence on the benefits of fiber-supplemented enteral nutrition (EN) in critically ill patients is inconsistent, and critical care nutrition guidelines lack recommendations based on high-quality evidence. Thi...
Pressure support, patient effort and tidal volume: a conceptual model for a non linear interaction
Pressure support ventilation (PSV) is a form of assisted ventilation which has become frequently used, with the aim of partially unloading the patient’s inspiratory muscles. Both under- and over-assistance sho...
Commenting on baricitinib versus tocilizumab in mechanically ventilated patients with COVID-19: a nationwide cohort study
The original article was published in Critical Care 2024 28 :282
What every intensivist needs to know about mpox
Transpulmonary pressure monitoring in critically ill patients: pros and cons—correction of description of the non-invasive peep-step method for separation of lung and chest wall mechanics.
The original article was published in Critical Care 2024 28 :177
Biochemical analysis of soft tissue infectious fluids and its diagnostic value in necrotizing soft tissue infections: a 5-year cohort study
Necrotizing soft tissue infections (NSTI) are rapidly progressing and life-threatening conditions that require prompt diagnosis. However, differentiating NSTI from other non-necrotizing skin and soft tissue in...
Development and functional characterization of a novel respiratory mask with full accordion cushioning to prevent air leaks and pressure injuries during non-invasive ventilation
A narrative review on lung injury: mechanisms, biomarkers, and monitoring.
Lung injury is closely associated with the heterogeneity, severity, mortality, and prognosis of various respiratory diseases. Effective monitoring of lung injury is crucial for the optimal management and impro...
Sex differences in extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: nationwide multicenter retrospective study in Japan
Previous studies examining sex differences in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) have indicated that women have favorable outcomes...
Effect of therapeutic plasma exchange on tissue factor and tissue factor pathway inhibitor in septic shock
Coagulopathy is part of the pathological host response to infection in sepsis. Higher plasma concentrations of both tissue factor (TF) and tissue factor pathway inhibitor (TFPI) are associated with occurrence ...
Airway epithelium damage in acute respiratory distress syndrome
The airway epithelium (AE) fulfils multiple functions to maintain pulmonary homeostasis, among which ensuring adequate barrier function, cell differentiation and polarization, and actively transporting immunog...
Interpretable machine learning model for new-onset atrial fibrillation prediction in critically ill patients: a multi-center study
New-onset atrial fibrillation (NOAF) is the most common arrhythmia in critically ill patients admitted to intensive care and is associated with poor prognosis and disease burden. Identifying high-risk individu...
Rezafungin versus caspofungin for patients with candidaemia or invasive candidiasis in the intensive care unit: pooled analyses of the ReSTORE and STRIVE randomised trials
Rezafungin is an echinocandin approved in the US and EU to treat candidaemia and/or invasive candidiasis. This post-hoc, pooled analysis of the Phase 2 STRIVE and Phase 3 ReSTORE trials assessed rezafungin ver...
Lack of up-to-date studies and data conversion may lead to biased results
The original article was published in Critical Care 2024 28 :158
Clinical impact of the implementation of monocyte distribution width (MDW) measurement on time to anti-infective administration in sepsis patients in the emergency department: a before/after cohort study
Timely recognition of sepsis in emergency department (ED) is challenging. We evaluated the impact of implementing the biomarker monocyte distribution width (MDW) at bedside, on the time to anti-infective admin...
Self-confidence as a mediator in the relationship between executive functioning and depression among ICU survivors: a latent variable analysis
Executive dysfunction and depression are common among ICU survivors, yet the mechanisms linking these two factors remain poorly understood. Self-confidence has been implicated as a key mediator in the relation...
Impact of low dose inhaled nitric oxide treatment in spontaneously breathing and intubated COVID-19 patients: a retrospective propensity-matched study
The benefit of Inhaled nitric oxide (iNO) therapy in the setting of COVID-19-related ARDS is obscure. We performed a multicenter retrospective study to evaluate the impact of iNO on patients with COVID-19 who ...
The Matters Arising to this article has been published in Critical Care 2024 28 :370
Identification of novel sub-phenotypes of severe ARDS requiring ECMO using latent class analysis
Sub-phenotyping of acute respiratory distress syndrome (ARDS) could be useful for evaluating the severity of ARDS or predicting its responsiveness to given therapeutic strategies, but no studies have yet inves...
A plea for enhanced monitoring of depth of sedation in patients who are intubated and ventilated
Comparison of electrical impedance tomography, blood gas analysis, and respiratory mechanics for positive end-expiratory pressure titration, an update on the mechanical versus manual cardiopulmonary resuscitation in cardiac arrest patients.
The original article was published in Critical Care 2024 28 :259
The original article was published in Critical Care 2024 28 :319
Incidence, predictability, and outcomes of systemic venous congestion following a fluid challenge in initially fluid-tolerant preload-responders after cardiac surgery: a pilot trial
Fluid administration has traditionally focused on preload responsiveness (PR). However, preventing fluid intolerance, particularly due to systemic venous congestion (VC), is equally important. This study evalu...
High-cost users after sepsis: a population-based observational cohort study
High-cost users (HCU) represent important targets for health policy interventions. Sepsis is a life-threatening syndrome that is associated with high morbidity, mortality, and economic costs to the healthcare ...
Cefiderocol pharmacokinetics in critically ill patients undergoing ECMO support
Regional ventilation dynamics of electrical impedance tomography validated with four-dimensional computed tomography: single-center, prospective, observational study.
The dynamic regional accuracy of electrical impedance tomography has not yet been validated. We aimed to compare the regional accuracy of electrical impedance tomography with that of four-dimensional computed ...
Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study
The aim of this study was to assess whether hypothermia increased survival and improved functional outcome when compared with normothermia in out-of-hospital cardiac arrest (OHCA) patients with similar charact...
A systematic review on the use of sevoflurane in the management of status asthmaticus in adults
To conduct a systematic review looking into the use of sevoflurane in the management of status asthmaticus (SA) in adults.
Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness: post- hoc analysis from the VICTAS trial
Sepsis and septic shock remain global healthcare problems associated with high mortality rates despite best therapy efforts. Circulating biomarkers may identify those patients at risk for poor outcomes, howeve...
Extracorporeal membrane oxygenation for tuberculosis-related acute respiratory distress syndrome: An international multicentre retrospective cohort study
To report the outcomes of patients with severe tuberculosis (TB)-related acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO), including predictors of 90-day mortality and a...
Impact of sleep disturbances on outcomes in intensive care units
Sleep deprivation is common in intensive care units (ICUs) and may alter respiratory performance. Few studies have assessed the role of sleep disturbances on outcomes in critically ill patients.
Blood trauma in veno-venous extracorporeal membrane oxygenation: low pump pressures and low circuit resistance matter
Veno-venous extracorporeal membrane oxygenation (VV ECMO) has become standard of care in patients with the most severe forms of acute respiratory distress syndrome. However, hemolysis and bleeding are one of t...
Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation
Airway pressure release ventilation (APRV) has been shown to be protective against atelectrauma if expirations are brief. We hypothesize that this is protective because epithelial surfaces are not given enough...
Nuts and bolts of lung ultrasound: utility, scanning techniques, protocols, and findings in common pathologies
Point of Care ultrasound (POCUS) of the lungs, also known as lung ultrasound (LUS), has emerged as a technique that allows for the diagnosis of many respiratory pathologies with greater accuracy and speed comp...
Correction to: Neurological monitoring and management for adult extracorporeal membrane oxygenation patients: Extracorporeal Life Support Organization consensus guidelines
The original article was published in Critical Care 2024 28 :296
Polymyxin-containing regimens for treating of pneumonia caused by multidrug-resistant gram-negative bacteria: Mind the breakpoints and the standardization of nebulization therapy
The original article was published in Critical Care 2024 28 :239
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Critical Care
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