The potential impact of coinfection on antimicrobial chemotherapy and drug resistance
COMMENTS
Global burden of bacterial antimicrobial resistance in 2019: a
Discussion. The global burden associated with drug-resistant infections assessed across 88 pathogen-drug combinations in 2019 was an estimated 4·95 million (95% UI 3·62-6·57) deaths, of which 1·27 million (0·911-1·71) deaths were directly attributable to drug resistance.
Antimicrobial resistance
Microbes can evolve antimicrobial resistance when, for example, populations are subjected to selective pressure through drug use in medicine. Latest Research and Reviews
Antimicrobial Resistance and Its Drivers—A Review
2. Antimicrobial Resistance: A Worldwide Public Health Emergency. In a recent estimate, about 3.57 million of 4.95 million deaths worldwide were associated with antimicrobial resistance in 2019 [], higher than many other well-known causes of mortality, including malaria and HIV/AIDS.According to the study, the worldwide burden of AMR is significantly higher than the 700,000 deaths per year ...
Evidence of Antibiotic Resistance from Population-Based Studies: A
The 20th century witnessed the dawn of the antibiotic revolution and is now facing the rising phenomenon of antibiotic resistance. In this narrative review, we aim to describe antibiotic resistance in clinical practice settings through population-based studies from different countries reporting the role of misuse of antibiotics in the development of resistance and the clinical and economic ...
Antimicrobial resistance: Impacts, challenges, and future prospects
1. Introduction. Antimicrobial resistance (AMR) has emerged as one of the most pressing global public health threats of the 21st century [1], [2], [3].AMR manifests when microorganisms, encompassing bacteria, fungi, parasites, and viruses, undergo evolutionary processes leading to their resistance against antimicrobial medications, such as antibiotics, commonly employed for treating such ...
Rising antimicrobial resistance: an evolving epidemic in a pandemic
While the second wave of the COVID-19 pandemic is sweeping through India, causing unprecedented human tragedy, the prescription of a plethora of unnecessary antibiotics—without regard for the potential for increased antimicrobial resistance—is widespread and unchecked. In The Lancet Microbe, Clark Russell and colleagues1 highlight the overuse of antimicrobials during the first wave of ...
Antibiotic resistance in the environment
Antibiotic resistance is a global health challenge, involving the transfer of bacteria and genes between humans, animals and the environment. Although multiple barriers restrict the flow of both ...
Molecular mechanisms of antibiotic resistance revisited
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. ... A Correction to this paper ...
Measuring the global response to antimicrobial resistance, 2020-21: a
To facilitate a comprehensive assessment of often multisectoral country activities on antimicrobial resistance, we also curated 26 composite indicator scores combined with insights drawn from manually screening NAPs, TrACSS, the Global Antimicrobial Resistance and Use Surveillance System (GLASS), the Global Antimicrobial Resistance Research and ...
Antimicrobial resistance: a global multifaceted phenomenon
Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. The first World Health Organization (WHO) Global report on surveillance of AMR, published in April 2014, collected for the first time data from national and international surveillance networks, showing the extent of this phenomenon in many parts of the world and also the presence of large ...
Decoding antimicrobial resistance: unraveling molecular mechanisms and
Antimicrobial resistance poses a significant global health threat, necessitating innovative approaches for combatting it. This review explores various mechanisms of antimicrobial resistance observed in various strains of bacteria. We examine various strategies, including antimicrobial peptides (AMPs), novel antimicrobial materials, drug delivery systems, vaccines, antibody therapies, and non ...
Global trend of antimicrobial resistance in common bacterial pathogens
1. Introduction. Since the discovery of penicillin in the 1920s, antimicrobial drugs have been regarded as the panacea to cure bacterial infections and have reduced the global burden of common infectious diseases (Van Boeckel et al., 2014, WHO, 2014); however, the widespread use of antimicrobial drugs is a major driving force for antibiotic resistance (Klein et al., 2018b).
The fight against antimicrobial resistance
The Indian government has long been aware of the risk that antimicrobial resistance poses to its citizens. Its 2017 National Health Policy 3 singled out antimicrobial resistance as an issue and ...
Antimicrobial resistance, mechanisms and its clinical significance
Abstract. Antimicrobial agents play a key role in controlling and curing infectious disease. Soon after the discovery of the first antibiotic, the challenge of antibiotic resistance commenced. Antimicrobial agents use different mechanisms against bacteria to prevent their pathogenesis and they can be classified as bactericidal or bacteriostatic.
Understanding and overcoming antibiotic resistance
In a PLOS Biology article, scientists show that intracellular expression of an antibiotic-metabolizing enzyme in a non-pathogenic strain of bacteria can provide resistance to the pathogen Streptococcus pneumoniae when the two types of bacteria are grown together, both in vitro and in vivo [ 3 ]. The expression of the metabolizing enzyme in the ...
Antibiotic Resistance in Bacteria—A Review
Mechanisms of Acquisition of Drug Resistance among Bacteria. The simplest type of resistance is a natural lack of susceptibility, called innate resistance. This is a constant trait of a species, strain, or whole group of bacteria. A given microorganism is insensitive to an antibiotic due to its 'innate' resistance to certain groups of ...
Bacterial Antibiotic Resistance: The Most Critical Pathogens
Understanding the resistance mechanisms of these bacteria is a key step in the development of new antimicrobial drugs to tackle drug-resistant bacteria. In this review, both the mode of action and the mechanisms of resistance of commonly used antimicrobials will be examined. It also discusses the current state of AMR in the most critical ...
WHO outlines 40 research priorities on antimicrobial resistance
WHO has published its first global research agenda for the world's scientists to address the most urgent human health priorities to combat antimicrobial resistance (AMR). It outlines 40 research topics on drug-resistant bacteria, fungi and Mycobacterium tuberculosis that must be answered by 2030, in line with the Sustainable Development Goals.. The WHO Global Research Agenda for AMR in human ...
Resisting antimicrobial resistance
To control antimicrobial resistance (AMR) will require approaches to develop, share and preserve antibiotics that are scaled to the scientific, economic and ethical dimensions of the crisis. The ...
The scope of the antimicrobial resistance challenge
This paper, the first in a Series on the challenge of antimicrobial resistance, considers the global scope of the problem and how it should be measured. Robust and actionable data are needed to drive changes and inform effective interventions to contain resistance. Surveillance must cover all geographical regions, minimise biases towards ...
Antibiotic resistance: a rundown of a global crisis
Introduction. Antibiotic resistance is ancient and the "resistome" is a dynamic and mounting problem. Causes of the global resistome are overpopulation, enhanced global migration, increased use of antibiotics in clinics and animal production, selection pressure, poor sanitation, wildlife spread, and poor sewerage disposal system. 1, 2 Antibiotic treatment is one of the main approaches of ...
Antibiotic-Free Treatment for Infection? New ...
In a world without antibiotics, a simple paper cut could lead to a deadly infection and infectious diseases were the leading cause of death. ... New Technology with Potential in the Fight Against Antimicrobial Resistance ... Commonly referred to as "superbugs," the rising rates of resistance combined with few new treatments in the research ...
Scientists identify mechanism behind drug resistance in malaria
In a paper titled "tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum", published in the journal Nature Microbiology, researchers from SMART's Antimicrobial Resistance (AMR) interdisciplinary research group documented their discovery: A change in a single tRNA, a small RNA molecule that is involved in translating genetic information from RNA to ...
Prevention of antibiotic resistance
The broader research field "antibiotic OR antimicrobial resistance" gave 431,335 hits. Narrowing the search criteria to "Prevention of antibiotic OR antimicrobial resistance" resulted in 1062 remaining titles. Of these, 622 were unique titles. ... Paper context. Antibiotic resistance is a threat to global security alongside terrorism ...
PDF Resisting antimicrobial resistance
Resisting antimicrobial resistance. To control antimicrobial resistance (AMR) will require approaches to develop, share and preserve antibiotics that are scaled to the scientific, economic and ...
The potential contribution of aquatic wildlife to antibiotic resistance
Antibiotic resistance (AR) is one of the major health threats of our time. The presence of antibiotics in the environment and their continuous release from sewage treatment plants, chemical manufacturing plants and animal husbandry, agriculture and aquaculture, result in constant selection pressure on microbial organisms. This presence leads to the emergence, mobilization, horizontal gene ...
Nanomaterial-based therapeutics for antibiotic-resistant bacterial
Antibiotic-resistant bacterial infections arising from acquired resistance and/or through biofilm formation necessitate the development of innovative 'outside of the box' therapeutics.
The Antibiotic Resistance Crisis
INTRODUCTION. The rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics, which have transformed medicine and saved millions of lives. 1 - 6 Many decades after the first patients were treated with antibiotics, bacterial infections have again become a threat. 7 The antibiotic resistance crisis has been attributed to the overuse and misuse of ...
IMAGES
VIDEO
COMMENTS
Discussion. The global burden associated with drug-resistant infections assessed across 88 pathogen-drug combinations in 2019 was an estimated 4·95 million (95% UI 3·62-6·57) deaths, of which 1·27 million (0·911-1·71) deaths were directly attributable to drug resistance.
Microbes can evolve antimicrobial resistance when, for example, populations are subjected to selective pressure through drug use in medicine. Latest Research and Reviews
2. Antimicrobial Resistance: A Worldwide Public Health Emergency. In a recent estimate, about 3.57 million of 4.95 million deaths worldwide were associated with antimicrobial resistance in 2019 [], higher than many other well-known causes of mortality, including malaria and HIV/AIDS.According to the study, the worldwide burden of AMR is significantly higher than the 700,000 deaths per year ...
The 20th century witnessed the dawn of the antibiotic revolution and is now facing the rising phenomenon of antibiotic resistance. In this narrative review, we aim to describe antibiotic resistance in clinical practice settings through population-based studies from different countries reporting the role of misuse of antibiotics in the development of resistance and the clinical and economic ...
1. Introduction. Antimicrobial resistance (AMR) has emerged as one of the most pressing global public health threats of the 21st century [1], [2], [3].AMR manifests when microorganisms, encompassing bacteria, fungi, parasites, and viruses, undergo evolutionary processes leading to their resistance against antimicrobial medications, such as antibiotics, commonly employed for treating such ...
While the second wave of the COVID-19 pandemic is sweeping through India, causing unprecedented human tragedy, the prescription of a plethora of unnecessary antibiotics—without regard for the potential for increased antimicrobial resistance—is widespread and unchecked. In The Lancet Microbe, Clark Russell and colleagues1 highlight the overuse of antimicrobials during the first wave of ...
Antibiotic resistance is a global health challenge, involving the transfer of bacteria and genes between humans, animals and the environment. Although multiple barriers restrict the flow of both ...
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. ... A Correction to this paper ...
To facilitate a comprehensive assessment of often multisectoral country activities on antimicrobial resistance, we also curated 26 composite indicator scores combined with insights drawn from manually screening NAPs, TrACSS, the Global Antimicrobial Resistance and Use Surveillance System (GLASS), the Global Antimicrobial Resistance Research and ...
Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. The first World Health Organization (WHO) Global report on surveillance of AMR, published in April 2014, collected for the first time data from national and international surveillance networks, showing the extent of this phenomenon in many parts of the world and also the presence of large ...
Antimicrobial resistance poses a significant global health threat, necessitating innovative approaches for combatting it. This review explores various mechanisms of antimicrobial resistance observed in various strains of bacteria. We examine various strategies, including antimicrobial peptides (AMPs), novel antimicrobial materials, drug delivery systems, vaccines, antibody therapies, and non ...
1. Introduction. Since the discovery of penicillin in the 1920s, antimicrobial drugs have been regarded as the panacea to cure bacterial infections and have reduced the global burden of common infectious diseases (Van Boeckel et al., 2014, WHO, 2014); however, the widespread use of antimicrobial drugs is a major driving force for antibiotic resistance (Klein et al., 2018b).
The Indian government has long been aware of the risk that antimicrobial resistance poses to its citizens. Its 2017 National Health Policy 3 singled out antimicrobial resistance as an issue and ...
Abstract. Antimicrobial agents play a key role in controlling and curing infectious disease. Soon after the discovery of the first antibiotic, the challenge of antibiotic resistance commenced. Antimicrobial agents use different mechanisms against bacteria to prevent their pathogenesis and they can be classified as bactericidal or bacteriostatic.
In a PLOS Biology article, scientists show that intracellular expression of an antibiotic-metabolizing enzyme in a non-pathogenic strain of bacteria can provide resistance to the pathogen Streptococcus pneumoniae when the two types of bacteria are grown together, both in vitro and in vivo [ 3 ]. The expression of the metabolizing enzyme in the ...
Mechanisms of Acquisition of Drug Resistance among Bacteria. The simplest type of resistance is a natural lack of susceptibility, called innate resistance. This is a constant trait of a species, strain, or whole group of bacteria. A given microorganism is insensitive to an antibiotic due to its 'innate' resistance to certain groups of ...
Understanding the resistance mechanisms of these bacteria is a key step in the development of new antimicrobial drugs to tackle drug-resistant bacteria. In this review, both the mode of action and the mechanisms of resistance of commonly used antimicrobials will be examined. It also discusses the current state of AMR in the most critical ...
WHO has published its first global research agenda for the world's scientists to address the most urgent human health priorities to combat antimicrobial resistance (AMR). It outlines 40 research topics on drug-resistant bacteria, fungi and Mycobacterium tuberculosis that must be answered by 2030, in line with the Sustainable Development Goals.. The WHO Global Research Agenda for AMR in human ...
To control antimicrobial resistance (AMR) will require approaches to develop, share and preserve antibiotics that are scaled to the scientific, economic and ethical dimensions of the crisis. The ...
This paper, the first in a Series on the challenge of antimicrobial resistance, considers the global scope of the problem and how it should be measured. Robust and actionable data are needed to drive changes and inform effective interventions to contain resistance. Surveillance must cover all geographical regions, minimise biases towards ...
Introduction. Antibiotic resistance is ancient and the "resistome" is a dynamic and mounting problem. Causes of the global resistome are overpopulation, enhanced global migration, increased use of antibiotics in clinics and animal production, selection pressure, poor sanitation, wildlife spread, and poor sewerage disposal system. 1, 2 Antibiotic treatment is one of the main approaches of ...
In a world without antibiotics, a simple paper cut could lead to a deadly infection and infectious diseases were the leading cause of death. ... New Technology with Potential in the Fight Against Antimicrobial Resistance ... Commonly referred to as "superbugs," the rising rates of resistance combined with few new treatments in the research ...
In a paper titled "tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum", published in the journal Nature Microbiology, researchers from SMART's Antimicrobial Resistance (AMR) interdisciplinary research group documented their discovery: A change in a single tRNA, a small RNA molecule that is involved in translating genetic information from RNA to ...
The broader research field "antibiotic OR antimicrobial resistance" gave 431,335 hits. Narrowing the search criteria to "Prevention of antibiotic OR antimicrobial resistance" resulted in 1062 remaining titles. Of these, 622 were unique titles. ... Paper context. Antibiotic resistance is a threat to global security alongside terrorism ...
Resisting antimicrobial resistance. To control antimicrobial resistance (AMR) will require approaches to develop, share and preserve antibiotics that are scaled to the scientific, economic and ...
Antibiotic resistance (AR) is one of the major health threats of our time. The presence of antibiotics in the environment and their continuous release from sewage treatment plants, chemical manufacturing plants and animal husbandry, agriculture and aquaculture, result in constant selection pressure on microbial organisms. This presence leads to the emergence, mobilization, horizontal gene ...
Antibiotic-resistant bacterial infections arising from acquired resistance and/or through biofilm formation necessitate the development of innovative 'outside of the box' therapeutics.
INTRODUCTION. The rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics, which have transformed medicine and saved millions of lives. 1 - 6 Many decades after the first patients were treated with antibiotics, bacterial infections have again become a threat. 7 The antibiotic resistance crisis has been attributed to the overuse and misuse of ...